STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PTGER3Prostaglandin E2 receptor EP3 subtype; Receptor for prostaglandin E2 (PGE2). Required for normal development of fever in response to pyrinogens, including IL1B, prostaglandin E2 and bacterial lipopolysaccharide (LPS). Required for normal potentiation of platelet aggregation by prostaglandin E2, and thus plays a role in the regulation of blood coagulation. Required for increased HCO3(-) secretion in the duodenum in response to mucosal acidification, and thereby contributes to the protection of the mucosa against acid-induced ulceration. Not required for normal kidney function, normal ur [...] (427 aa)    
Predicted Functional Partners:
GNAI1
Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.
   
 0.951
GNAI3
Guanine nucleotide-binding protein G(K) subunit alpha.
    
 0.939
GNAI2
G protein subunit alpha i2.
    
 0.939
GNAO1
Guanine nucleotide-binding protein G(O) subunit alpha isoform b.
    
 0.934
GNAS-2
Guanine nucleotide-binding protein G(s) subunit alpha.
    
  0.906
GNB2
G protein subunit beta 2.
    
 0.817
GNB4
G protein subunit beta 4.
    
 0.817
GNB1
G protein subunit beta 1.
    
 0.801
GNG2
Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.
    
  0.799
GNB3
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.
    
 0.791
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.