node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABHD6 | DAGLA | ENSSSCP00000038285 | ENSSSCP00000013911 | Abhydrolase domain containing 6. | Diacylglycerol lipase alpha. | 0.827 |
ABHD6 | FAAH | ENSSSCP00000038285 | ENSSSCP00000050676 | Abhydrolase domain containing 6. | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. | 0.933 |
ABHD6 | GPR55 | ENSSSCP00000038285 | ENSSSCP00000038940 | Abhydrolase domain containing 6. | G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. | 0.484 |
ABHD6 | LOC102164418 | ENSSSCP00000038285 | ENSSSCP00000046471 | Abhydrolase domain containing 6. | Amidase domain-containing protein. | 0.756 |
ABHD6 | NAPEPLD | ENSSSCP00000038285 | ENSSSCP00000050861 | Abhydrolase domain containing 6. | N-acyl phosphatidylethanolamine phospholipase D. | 0.895 |
CNR1 | DAGLA | ENSSSCP00000069188 | ENSSSCP00000013911 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Diacylglycerol lipase alpha. | 0.722 |
CNR1 | FAAH | ENSSSCP00000069188 | ENSSSCP00000050676 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. | 0.873 |
CNR1 | GPR55 | ENSSSCP00000069188 | ENSSSCP00000038940 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. | 0.812 |
CNR1 | LOC102164418 | ENSSSCP00000069188 | ENSSSCP00000046471 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Amidase domain-containing protein. | 0.661 |
CNR1 | NAPEPLD | ENSSSCP00000069188 | ENSSSCP00000050861 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | N-acyl phosphatidylethanolamine phospholipase D. | 0.699 |
CNR1 | TRPV1 | ENSSSCP00000069188 | ENSSSCP00000058489 | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | Transient receptor potential cation channel subfamily V member 1; Belongs to the transient receptor (TC 1.A.4) family. | 0.621 |
DAGLA | ABHD6 | ENSSSCP00000013911 | ENSSSCP00000038285 | Diacylglycerol lipase alpha. | Abhydrolase domain containing 6. | 0.827 |
DAGLA | CNR1 | ENSSSCP00000013911 | ENSSSCP00000069188 | Diacylglycerol lipase alpha. | Cannabinoid receptor 1; G-protein coupled receptor for cannabinoids (eCBs), including N-arachidonoylethanolamide (also called anandamide or AEA) and 2- arachidonoylglycerol (2-AG). Mediates many cannabinoid-induced effects, acting, among others, on food intake, memory loss, gastrointestinal motility, catalepsy, ambulatory activity, anxiety, chronic pain. Signaling typically involves reduction in cyclic AMP. In the hypothalamus, may have a dual effect on mitochondrial respiration depending upon the agonist dose and possibly upon the cell type. Increases respiration at low doses, while d [...] | 0.722 |
DAGLA | FAAH | ENSSSCP00000013911 | ENSSSCP00000050676 | Diacylglycerol lipase alpha. | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. | 0.808 |
DAGLA | GPR55 | ENSSSCP00000013911 | ENSSSCP00000038940 | Diacylglycerol lipase alpha. | G-protein coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. | 0.574 |
DAGLA | LOC102164418 | ENSSSCP00000013911 | ENSSSCP00000046471 | Diacylglycerol lipase alpha. | Amidase domain-containing protein. | 0.557 |
DAGLA | NAPEPLD | ENSSSCP00000013911 | ENSSSCP00000050861 | Diacylglycerol lipase alpha. | N-acyl phosphatidylethanolamine phospholipase D. | 0.865 |
DARS2 | EPRS1 | ENSSSCP00000036160 | ENSSSCP00000034014 | Aspartyl-tRNA synthetase 2, mitochondrial. | Glutamyl-prolyl-tRNA synthetase. | 0.963 |
DARS2 | FAAH | ENSSSCP00000036160 | ENSSSCP00000050676 | Aspartyl-tRNA synthetase 2, mitochondrial. | Fatty-acid amide hydrolase 1; Degrades bioactive fatty acid amides like oleamide, the endogenous cannabinoid, anandamide and myristic amide to their corresponding acids, thereby serving to terminate the signaling functions of these molecules. Hydrolyzes polyunsaturated substrate anandamide preferentially as compared to monounsaturated substrates (By similarity); Belongs to the amidase family. | 0.893 |
DARS2 | GATB | ENSSSCP00000036160 | ENSSSCP00000073019 | Aspartyl-tRNA synthetase 2, mitochondrial. | Glutamyl-tRNA(Gln) amidotransferase subunit B, mitochondrial; Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Belongs to the GatB/GatE family. GatB subfamily. | 0.987 |