OPRM1 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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structured XML interaction data, according to the 'PSI-MI' data standard

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a tab-delimited file describing the names, domains and descriptions of proteins in your network

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a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAI1	GNAO1	ENSSSCP00000016334	ENSSSCP00000040441	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	0.981
GNAI1	GNB2	ENSSSCP00000016334	ENSSSCP00000008190	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	G protein subunit beta 2.	0.996
GNAI1	GNB3	ENSSSCP00000016334	ENSSSCP00000000727	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.	0.995
GNAI1	GNB4	ENSSSCP00000016334	ENSSSCP00000036910	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	G protein subunit beta 4.	0.996
GNAI1	GNB5	ENSSSCP00000016334	ENSSSCP00000031679	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	G protein subunit beta 5.	0.995
GNAI1	GNG2	ENSSSCP00000016334	ENSSSCP00000024099	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.997
GNAI1	OPRD1	ENSSSCP00000016334	ENSSSCP00000024665	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...]	0.951
GNAI1	OPRM1	ENSSSCP00000016334	ENSSSCP00000004401	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.962
GNAO1	GNAI1	ENSSSCP00000040441	ENSSSCP00000016334	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	0.981
GNAO1	GNB2	ENSSSCP00000040441	ENSSSCP00000008190	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	G protein subunit beta 2.	0.998
GNAO1	GNB3	ENSSSCP00000040441	ENSSSCP00000000727	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.	0.997
GNAO1	GNB4	ENSSSCP00000040441	ENSSSCP00000036910	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	G protein subunit beta 4.	0.998
GNAO1	GNB5	ENSSSCP00000040441	ENSSSCP00000031679	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	G protein subunit beta 5.	0.997
GNAO1	GNG2	ENSSSCP00000040441	ENSSSCP00000024099	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.997
GNAO1	OPRD1	ENSSSCP00000040441	ENSSSCP00000024665	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...]	0.913
GNAO1	OPRM1	ENSSSCP00000040441	ENSSSCP00000004401	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	Mu-type opioid receptor; Receptor for endogenous opioids such as beta-endorphin and endomorphin. Receptor for natural and synthetic opioids including morphine, heroin, DAMGO, fentanyl, etorphine, buprenorphin and methadone. Agonist binding to the receptor induces coupling to an inactive GDP-bound heterotrimeric G-protein complex and subsequent exchange of GDP for GTP in the G-protein alpha subunit leading to dissociation of the G-protein complex with the free GTP-bound G-protein alpha and the G-protein beta-gamma dimer activating downstream cellular effectors. The agonist- and cell typ [...]	0.967
GNB2	GNAI1	ENSSSCP00000008190	ENSSSCP00000016334	G protein subunit beta 2.	Guanine nucleotide-binding protein G(I) subunit alpha-1 isoform 1.	0.996
GNB2	GNAO1	ENSSSCP00000008190	ENSSSCP00000040441	G protein subunit beta 2.	Guanine nucleotide-binding protein G(O) subunit alpha isoform b.	0.998
GNB2	GNB3	ENSSSCP00000008190	ENSSSCP00000000727	G protein subunit beta 2.	Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 1.	0.985
GNB2	GNB4	ENSSSCP00000008190	ENSSSCP00000036910	G protein subunit beta 2.	G protein subunit beta 4.	0.966