Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
MAN1A1Mannosyl-oligosaccharide 1,2-alpha-mannosidase IA; Involved in the maturation of Asn-linked oligosaccharides. Progressively trim alpha-1,2-linked mannose residues from Man(9)GlcNAc(2) to produce Man(5)GlcNAc(2). (837 aa)    
Predicted Functional Partners:
MGAT1
Mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase.
    
 0.969
MAN1A2
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
     
  0.919
MAN1C1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
     
  0.919
LOC110258087
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
   
 0.766
MAN1B1
alpha-1,2-Mannosidase; Belongs to the glycosyl hydrolase 47 family.
   
 0.766
MGAT2
Alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; Plays an essential role in protein N-glycosylation. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) onto the free terminal mannose moiety in the core structure of the nascent N-linked glycan chain, giving rise to the second branch in complex glycans. Belongs to the glycosyltransferase 16 (GT16) protein family.
   
 
 0.720
MAN2A1
Alpha-mannosidase.
   
  
 0.683
GANAB
Neutral alpha-glucosidase AB; Catalytic subunit of glucosidase II that cleaves sequentially the 2 innermost alpha-1,3-linked glucose residues from the Glc(2)Man(9)GlcNAc(2) oligosaccharide precursor of immature glycoproteins. Required for PKD1/Polycystin-1 and PKD2/Polycystin-2 maturation and localization to the cell surface and cilia.
   
 
 0.681
ALG5
Glyco_trans_2-like domain-containing protein.
      
 0.673
MAN2A2
Alpha-mannosidase.
   
  
 0.670
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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