STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TBX18T-box transcription factor TBX18. (612 aa)    
Predicted Functional Partners:
SHOX2
Short stature homeobox 2.
   
 
 0.873
TCF21
Transcription factor 21.
      
 0.800
WT1
Wilms tumor protein homolog; Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isofor [...]
      
 0.789
HCN4
Hyperpolarization activated cyclic nucleotide gated potassium channel 4.
      
 0.777
ISL1
Insulin gene enhancer protein ISL-1.
    
 
 0.702
SEMA3D
Semaphorin-3D isoform X1; Belongs to the semaphorin family.
      
 0.665
NKX2-5
NK2 homeobox 5.
    
 
 0.662
IRX4
Iroquois-class homeodomain protein IRX-4 isoform b.
    
 
 0.577
WARS2
Uncharacterized protein; Belongs to the class-I aminoacyl-tRNA synthetase family.
      
 0.565
ALDH1A2
Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family.
      
 0.562
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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