ME1 protein (Sus scrofa) - STRING interaction network

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Score

ME1

NADP-dependent malic enzyme; Belongs to the malic enzymes family. (571 aa)

Predicted Functional Partners:

FH

0.985

MDH1

0.983

MDH2

0.971

CS

0.964

PDHB

0.956

PDHA1

0.954

PKLR

0.951

PKM

0.951

LDHC

0.937

LDHA

0.937

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CS	FH	ENSSSCP00000056310	ENSSSCP00000046547	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	0.975
CS	LDHA	ENSSSCP00000056310	ENSSSCP00000036508	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	L-lactate dehydrogenase A chain.	0.879
CS	LDHC	ENSSSCP00000056310	ENSSSCP00000014199	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	L-lactate dehydrogenase C chain; Possible role in sperm motility.	0.868
CS	MDH1	ENSSSCP00000056310	ENSSSCP00000062430	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Malate dehydrogenase, cytoplasmic.	0.995
CS	MDH2	ENSSSCP00000056310	ENSSSCP00000070379	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Malate dehydrogenase, mitochondrial.	0.998
CS	ME1	ENSSSCP00000056310	ENSSSCP00000071155	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	NADP-dependent malic enzyme; Belongs to the malic enzymes family.	0.964
CS	PDHA1	ENSSSCP00000056310	ENSSSCP00000029133	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	0.812
CS	PDHB	ENSSSCP00000056310	ENSSSCP00000065067	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.919
CS	PKLR	ENSSSCP00000056310	ENSSSCP00000036804	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Pyruvate kinase; Belongs to the pyruvate kinase family.	0.422
CS	PKM	ENSSSCP00000056310	ENSSSCP00000051975	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	Multifunctional fusion protein; Belongs to the pyruvate kinase family.	0.467
FH	CS	ENSSSCP00000046547	ENSSSCP00000056310	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	0.975
FH	LDHA	ENSSSCP00000046547	ENSSSCP00000036508	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	L-lactate dehydrogenase A chain.	0.633
FH	LDHC	ENSSSCP00000046547	ENSSSCP00000014199	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	L-lactate dehydrogenase C chain; Possible role in sperm motility.	0.633
FH	MDH1	ENSSSCP00000046547	ENSSSCP00000062430	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Malate dehydrogenase, cytoplasmic.	0.989
FH	MDH2	ENSSSCP00000046547	ENSSSCP00000070379	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Malate dehydrogenase, mitochondrial.	0.997
FH	ME1	ENSSSCP00000046547	ENSSSCP00000071155	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	NADP-dependent malic enzyme; Belongs to the malic enzymes family.	0.985
FH	PDHA1	ENSSSCP00000046547	ENSSSCP00000029133	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle.	0.599
FH	PDHB	ENSSSCP00000046547	ENSSSCP00000065067	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Pyruvate dehydrogenase E1 component subunit beta; The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2.	0.503
FH	PKM	ENSSSCP00000046547	ENSSSCP00000051975	Fumarate hydratase, mitochondrial; Catalyzes the reversible stereospecific interconversion of fumarate to L-malate. Experiments in different species have demonstrated that specific isoforms of this protein act in defined pathways and favor one direction over the other (Probable). [Isoform Cytoplasmic]: Catalyzes the dehydration of L-malate to fumarate. Fumarate metabolism in the cytosol plays a role during urea cycle and arginine metabolism; fumarate being a by-product of the urea cycle and amino-acid catabolism (By similarity). Also plays a role in DNA repair by promoting non-homolog [...]	Multifunctional fusion protein; Belongs to the pyruvate kinase family.	0.443
LDHA	CS	ENSSSCP00000036508	ENSSSCP00000056310	L-lactate dehydrogenase A chain.	Citrate synthase, mitochondrial; Belongs to the citrate synthase family.	0.879