node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
E2F4 | LEF1 | ENSSSCP00000037021 | ENSSSCP00000033976 | E2F transcription factor 4. | Lymphoid enhancer binding factor 1. | 0.409 |
E2F4 | SMAD2 | ENSSSCP00000037021 | ENSSSCP00000054408 | E2F transcription factor 4. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.819 |
E2F4 | SMAD3 | ENSSSCP00000037021 | ENSSSCP00000073915 | E2F transcription factor 4. | Mothers against decapentaplegic homolog. | 0.972 |
E2F4 | SMAD4 | ENSSSCP00000037021 | ENSSSCP00000004879 | E2F transcription factor 4. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.958 |
LEF1 | E2F4 | ENSSSCP00000033976 | ENSSSCP00000037021 | Lymphoid enhancer binding factor 1. | E2F transcription factor 4. | 0.409 |
LEF1 | SMAD2 | ENSSSCP00000033976 | ENSSSCP00000054408 | Lymphoid enhancer binding factor 1. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.660 |
LEF1 | SMAD3 | ENSSSCP00000033976 | ENSSSCP00000073915 | Lymphoid enhancer binding factor 1. | Mothers against decapentaplegic homolog. | 0.633 |
LEF1 | SMAD4 | ENSSSCP00000033976 | ENSSSCP00000004879 | Lymphoid enhancer binding factor 1. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.988 |
SKI | SMAD1 | ENSSSCP00000042897 | ENSSSCP00000032660 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.836 |
SKI | SMAD2 | ENSSSCP00000042897 | ENSSSCP00000054408 | SKI proto-oncogene. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.873 |
SKI | SMAD3 | ENSSSCP00000042897 | ENSSSCP00000073915 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.786 |
SKI | SMAD4 | ENSSSCP00000042897 | ENSSSCP00000004879 | SKI proto-oncogene. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.981 |
SKI | SMAD5 | ENSSSCP00000042897 | ENSSSCP00000032987 | SKI proto-oncogene. | Mothers against decapentaplegic homolog. | 0.822 |
SMAD1 | SKI | ENSSSCP00000032660 | ENSSSCP00000042897 | Mothers against decapentaplegic homolog. | SKI proto-oncogene. | 0.836 |
SMAD1 | SMAD2 | ENSSSCP00000032660 | ENSSSCP00000054408 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | 0.594 |
SMAD1 | SMAD3 | ENSSSCP00000032660 | ENSSSCP00000073915 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.932 |
SMAD1 | SMAD4 | ENSSSCP00000032660 | ENSSSCP00000004879 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog 4; Common SMAD (co-SMAD) is the coactivator and mediator of signal transduction by TGF-beta (transforming growth factor). Component of the heterotrimeric SMAD2/SMAD3-SMAD4 complex that forms in the nucleus and is required for the TGF-mediated signaling. Promotes binding of the SMAD2/SMAD4/FAST-1 complex to DNA and provides an activation function required for SMAD1 or SMAD2 to stimulate transcription. Component of the multimeric SMAD3/SMAD4/JUN/FOS complex which forms at the AP1 promoter site; required for synergistic transcriptional activity in r [...] | 0.994 |
SMAD1 | SMAD5 | ENSSSCP00000032660 | ENSSSCP00000032987 | Mothers against decapentaplegic homolog. | Mothers against decapentaplegic homolog. | 0.936 |
SMAD1 | TGFBR1 | ENSSSCP00000032660 | ENSSSCP00000030910 | Mothers against decapentaplegic homolog. | TGF-beta receptor type-1; Transmembrane serine/threonine kinase forming with the TGF- beta type II serine/threonine kinase receptor, TGFBR2, the non- promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinog [...] | 0.654 |
SMAD2 | E2F4 | ENSSSCP00000054408 | ENSSSCP00000037021 | Mothers against decapentaplegic homolog 3; Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD3/SMAD4 complex, activates transcription. Also can form a SMAD3/SMAD4/JUN/FOS complex at the AP- 1/SMAD site to regulate TGF-beta-mediated transcription. Has an inhibitory effect on wound healing probably by modulating both growth and m [...] | E2F transcription factor 4. | 0.819 |