| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| COPS5 | COPS6 | ENSSSCP00000040435 | ENSSSCP00000041142 | COP9 signalosome subunit 5. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.997 |
| COPS5 | PSMC3 | ENSSSCP00000040435 | ENSSSCP00000068006 | COP9 signalosome subunit 5. | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.516 |
| COPS5 | PSMC6 | ENSSSCP00000040435 | ENSSSCP00000054995 | COP9 signalosome subunit 5. | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. | 0.795 |
| COPS5 | PSMD13 | ENSSSCP00000040435 | ENSSSCP00000066356 | COP9 signalosome subunit 5. | Proteasome 26S subunit, non-ATPase 13. | 0.755 |
| COPS5 | PSMD14 | ENSSSCP00000040435 | ENSSSCP00000057773 | COP9 signalosome subunit 5. | 26S proteasome non-ATPase regulatory subunit 14. | 0.588 |
| COPS5 | TXNL1 | ENSSSCP00000040435 | ENSSSCP00000004891 | COP9 signalosome subunit 5. | Thioredoxin like 1. | 0.856 |
| COPS6 | COPS5 | ENSSSCP00000041142 | ENSSSCP00000040435 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | COP9 signalosome subunit 5. | 0.997 |
| COPS6 | PSMC3 | ENSSSCP00000041142 | ENSSSCP00000068006 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 0.855 |
| COPS6 | PSMC6 | ENSSSCP00000041142 | ENSSSCP00000054995 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. | 0.495 |
| COPS6 | PSMD13 | ENSSSCP00000041142 | ENSSSCP00000066356 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | Proteasome 26S subunit, non-ATPase 13. | 0.757 |
| COPS6 | PSMD14 | ENSSSCP00000041142 | ENSSSCP00000057773 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 26S proteasome non-ATPase regulatory subunit 14. | 0.539 |
| COPS6 | TXNL1 | ENSSSCP00000041142 | ENSSSCP00000004891 | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | Thioredoxin like 1. | 0.661 |
| MRPS33 | TXNL1 | ENSSSCP00000014318 | ENSSSCP00000004891 | Mitochondrial ribosomal protein S33. | Thioredoxin like 1. | 0.595 |
| PDXP | TXNL1 | ENSSSCP00000049447 | ENSSSCP00000004891 | Pyridoxal phosphatase; Belongs to the HAD-like hydrolase superfamily. | Thioredoxin like 1. | 0.661 |
| PSMC3 | COPS5 | ENSSSCP00000068006 | ENSSSCP00000040435 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | COP9 signalosome subunit 5. | 0.516 |
| PSMC3 | COPS6 | ENSSSCP00000068006 | ENSSSCP00000041142 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.855 |
| PSMC3 | PSMC6 | ENSSSCP00000068006 | ENSSSCP00000054995 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. | 0.995 |
| PSMC3 | PSMD13 | ENSSSCP00000068006 | ENSSSCP00000066356 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Proteasome 26S subunit, non-ATPase 13. | 0.998 |
| PSMC3 | PSMD14 | ENSSSCP00000068006 | ENSSSCP00000057773 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | 26S proteasome non-ATPase regulatory subunit 14. | 0.999 |
| PSMC3 | TXNL1 | ENSSSCP00000068006 | ENSSSCP00000004891 | Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. | Thioredoxin like 1. | 0.590 |