node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ATP2A1 | ATP2A2 | ENSSSCP00000044701 | ENSSSCP00000037774 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.910 |
ATP2A1 | ATP2A3 | ENSSSCP00000044701 | ENSSSCP00000033739 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A1 | RORA | ENSSSCP00000044701 | ENSSSCP00000004933 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | RAR related orphan receptor A. | 0.900 |
ATP2A2 | ATP2A1 | ENSSSCP00000037774 | ENSSSCP00000044701 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.910 |
ATP2A2 | ATP2A3 | ENSSSCP00000037774 | ENSSSCP00000033739 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A2 | ITPR1 | ENSSSCP00000037774 | ENSSSCP00000064275 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | Inositol 1,4,5-trisphosphate receptor type 1. | 0.466 |
ATP2A2 | RORA | ENSSSCP00000037774 | ENSSSCP00000004933 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | RAR related orphan receptor A. | 0.903 |
ATP2A3 | ATP2A1 | ENSSSCP00000033739 | ENSSSCP00000044701 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.904 |
ATP2A3 | ATP2A2 | ENSSSCP00000033739 | ENSSSCP00000037774 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.904 |
ATP2A3 | GRM1 | ENSSSCP00000033739 | ENSSSCP00000047603 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | Glutamate metabotropic receptor 1. | 0.438 |
ATP2A3 | RORA | ENSSSCP00000033739 | ENSSSCP00000004933 | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | RAR related orphan receptor A. | 0.900 |
GRM1 | ATP2A3 | ENSSSCP00000047603 | ENSSSCP00000033739 | Glutamate metabotropic receptor 1. | Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. | 0.438 |
GRM1 | ITPR1 | ENSSSCP00000047603 | ENSSSCP00000064275 | Glutamate metabotropic receptor 1. | Inositol 1,4,5-trisphosphate receptor type 1. | 0.497 |
GRM1 | RORA | ENSSSCP00000047603 | ENSSSCP00000004933 | Glutamate metabotropic receptor 1. | RAR related orphan receptor A. | 0.936 |
ITPR1 | ATP2A2 | ENSSSCP00000064275 | ENSSSCP00000037774 | Inositol 1,4,5-trisphosphate receptor type 1. | Sarcoplasmic/endoplasmic reticulum calcium ATPase 2; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the translocation of calcium from the cytosol to the sarcoplasmic reticulum lumen. Isoform SERCA2A is involved in the regulation of the contraction/relaxation cycle. Acts as a regulator of TNFSF11-mediated Ca(2+) signaling pathways via its interaction with TMEM64 which is critical for the TNFSF11-induced CREB1 activation and mitochondrial ROS generation necessary for proper osteoclast generation. Association between TMEM64 and SERCA2 in the ER leads to cytos [...] | 0.466 |
ITPR1 | GRM1 | ENSSSCP00000064275 | ENSSSCP00000047603 | Inositol 1,4,5-trisphosphate receptor type 1. | Glutamate metabotropic receptor 1. | 0.497 |
ITPR1 | RORA | ENSSSCP00000064275 | ENSSSCP00000004933 | Inositol 1,4,5-trisphosphate receptor type 1. | RAR related orphan receptor A. | 0.907 |
ITPR1 | TRPC3 | ENSSSCP00000064275 | ENSSSCP00000009701 | Inositol 1,4,5-trisphosphate receptor type 1. | Transient receptor potential cation channel subfamily C member 3; Belongs to the transient receptor (TC 1.A.4) family. | 0.534 |
NRIP1 | RORA | ENSSSCP00000061061 | ENSSSCP00000004933 | Nuclear receptor-interacting protein 1 isoform X1. | RAR related orphan receptor A. | 0.752 |
NRIP1 | RORB | ENSSSCP00000061061 | ENSSSCP00000070829 | Nuclear receptor-interacting protein 1 isoform X1. | RAR related orphan receptor B. | 0.504 |