STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
FBN1Fibrillin-1; [Fibrillin-1]: Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. Fibrillin-1-containing microfibrils provide long-term force bearing structural support. In tissues such as the lung, blood vessels and skin, microfibrils form the periphery of the elastic fiber, acting as a scaffold for the deposition of elastin. In addition, microfibrils can occur as elastin-independent networks in tissues such as the ciliary zonule, tendon, cornea and glomerulus [...] (2871 aa)    
Predicted Functional Partners:
LUM
Lumican.
   
 
 0.983
MMP2
Uncharacterized protein.
   
 
 0.971
DCN
Decorin; May affect the rate of fibrils formation.
   
 
 0.931
ELN
Elastin.
   
 
 0.917
COL5A2
Collagen alpha-2(V) chain preproprotein.
   
 
 0.902
COL3A1
Collagen alpha-1(III) chain preproprotein.
   
 
 0.881
COL1A2
Fibrillar collagen NC1 domain-containing protein.
   
 
 0.867
LOXL1
Lysyl oxidase like 1.
   
 
 0.836
COL1A1
Collagen type I alpha 1 chain.
   
 
 0.811
ADAMTS10
Uncharacterized protein.
    
 
 0.810
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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