STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
SCG5Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. (211 aa)    
Predicted Functional Partners:
PCSK2
Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity).
   
 
 0.929
ARHGAP11A
Rho GTPase activating protein 11A.
 
    
 0.855
PCSK5
Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family.
   
 
 0.807
SCG2
Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.
   
  
 0.789
CHGB
Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides.
   
  
 0.778
SCG3
Secretogranin III.
   
  
 0.739
PCSK4
Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family.
   
 
 0.722
PCSK7
Proprotein convertase subtilisin/kexin type 7.
   
 
 0.704
MBTPS1
Membrane bound transcription factor peptidase, site 1.
   
 
 0.691
MAK16
Protein MAK16 homolog; Belongs to the MAK16 family.
      
 0.675
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
Server load: medium (50%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.