node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ARHGAP11A | SCG5 | ENSSSCP00000005175 | ENSSSCP00000005176 | Rho GTPase activating protein 11A. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.834 |
CHGB | PCSK2 | ENSSSCP00000034002 | ENSSSCP00000007546 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | 0.593 |
CHGB | PCSK7 | ENSSSCP00000034002 | ENSSSCP00000015996 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Proprotein convertase subtilisin/kexin type 7. | 0.473 |
CHGB | SCG2 | ENSSSCP00000034002 | ENSSSCP00000040210 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.919 |
CHGB | SCG3 | ENSSSCP00000034002 | ENSSSCP00000044507 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Secretogranin III. | 0.766 |
CHGB | SCG5 | ENSSSCP00000034002 | ENSSSCP00000005176 | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.730 |
MBTPS1 | PCSK4 | ENSSSCP00000002896 | ENSSSCP00000027290 | Membrane bound transcription factor peptidase, site 1. | Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. | 0.709 |
MBTPS1 | PCSK5 | ENSSSCP00000002896 | ENSSSCP00000057080 | Membrane bound transcription factor peptidase, site 1. | Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. | 0.677 |
MBTPS1 | PCSK6 | ENSSSCP00000002896 | ENSSSCP00000006199 | Membrane bound transcription factor peptidase, site 1. | Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. | 0.626 |
MBTPS1 | PCSK7 | ENSSSCP00000002896 | ENSSSCP00000015996 | Membrane bound transcription factor peptidase, site 1. | Proprotein convertase subtilisin/kexin type 7. | 0.822 |
MBTPS1 | SCG5 | ENSSSCP00000002896 | ENSSSCP00000005176 | Membrane bound transcription factor peptidase, site 1. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.707 |
PCSK2 | CHGB | ENSSSCP00000007546 | ENSSSCP00000034002 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Secretogranin-1; Secretogranin-1 is a neuroendocrine secretory granule protein, which may be the precursor for other biologically active peptides. | 0.593 |
PCSK2 | SCG2 | ENSSSCP00000007546 | ENSSSCP00000040210 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Secretogranin-2; Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules. | 0.455 |
PCSK2 | SCG5 | ENSSSCP00000007546 | ENSSSCP00000005176 | Neuroendocrine convertase 2; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Responsible for the release of glucagon from proglucagon in pancreatic A cells (By similarity). | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.816 |
PCSK4 | MBTPS1 | ENSSSCP00000027290 | ENSSSCP00000002896 | Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. | Membrane bound transcription factor peptidase, site 1. | 0.709 |
PCSK4 | SCG5 | ENSSSCP00000027290 | ENSSSCP00000005176 | Proprotein convertase subtilisin/kexin type 4; Belongs to the peptidase S8 family. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.709 |
PCSK5 | MBTPS1 | ENSSSCP00000057080 | ENSSSCP00000002896 | Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. | Membrane bound transcription factor peptidase, site 1. | 0.677 |
PCSK5 | SCG5 | ENSSSCP00000057080 | ENSSSCP00000005176 | Proprotein convertase subtilisin/kexin type 5; Belongs to the peptidase S8 family. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.692 |
PCSK6 | MBTPS1 | ENSSSCP00000006199 | ENSSSCP00000002896 | Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. | Membrane bound transcription factor peptidase, site 1. | 0.626 |
PCSK6 | SCG5 | ENSSSCP00000006199 | ENSSSCP00000005176 | Proprotein convertase subtilisin/kexin type 6 isoform PACE4-AI preproprotein; Belongs to the peptidase S8 family. | Neuroendocrine protein 7B2; Acts as a molecular chaperone for PCSK2/PC2, preventing its premature activation in the regulated secretory pathway. Binds to inactive PCSK2 in the endoplasmic reticulum and facilitates its transport from there to later compartments of the secretory pathway where it is proteolytically matured and activated. Also required for cleavage of PCSK2 but does not appear to be involved in its folding. Plays a role in regulating pituitary hormone secretion. The C-terminal peptide inhibits PCSK2 in vitro. | 0.648 |