STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SLC51BOrganic solute transporter subunit beta. (131 aa)    
Predicted Functional Partners:
SLC51A
Solute carrier family 51 alpha subunit.
   
 
 0.990
SLC10A2
Uncharacterized protein.
   
  
 0.735
CYP8B1
5-beta-cholestane-3-alpha,7-alpha-diol 12-alpha-hydroxylase; Involved in bile acid synthesis and is responsible for the conversion of 5 beta-cholestane-3-alpha,7-alpha-diol into 5 beta- cholestane-3-alpha,7-alpha,12-alpha triol. Responsible for the balance between formation of cholic acid and chenodeoxycholic acid. The enzyme can also hydroxylate the substrate at the 25 and 26 position, but to a lesser extent.
   
  
 0.684
FABP6
Gastrotropin; Binds to bile acids and is involved in enterohepatic bile acid metabolism. Required for efficient apical to basolateral transport of conjugated bile acids in ileal enterocytes (By similarity). Stimulates gastric acid and pepsinogen secretion. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
      
 0.604
NR1H4
Nuclear receptor subfamily 1 group H member 4.
   
  
 0.603
CYP7A1
Cytochrome P450 7A1; A cytochrome P450 monooxygenase involved in the metabolism of endogenous cholesterol and its oxygenated derivatives (oxysterols). Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (CPR; NADPH- ferrihemoprotein reductase). Functions as a critical regulatory enzyme of bile acid biosynthesis and cholesterol homeostasis. Catalyzes the hydroxylation of carbon hydrogen bond at 7-alpha position of cholesterol, a rate-limiting s [...]
   
  
 0.581
SLC10A1
Solute carrier family 10 member 1.
   
  
 0.578
AKR1D1
3-oxo-5-beta-steroid 4-dehydrogenase isoform 1.
   
  
 0.574
SLCO1B3
Solute carrier organic anion transporter family member.
      
 0.569
ABCB11
ATP binding cassette subfamily B member 11.
   
  
 0.562
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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