STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IFNEInterferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. (193 aa)    
Predicted Functional Partners:
IFNAR1
Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity).
   
 0.977
CSF3R
Granulocyte colony-stimulating factor receptor.
   
 
 0.821
IFNGR2
Interferon gamma receptor 2 isoform 1.
   
 
 0.766
IL20RA
Interleukin 20 receptor subunit alpha.
     
 0.766
DEFB112
Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family.
      
 0.750
IL10RB
Interleukin-10 receptor subunit beta.
   
 0.746
IFNGR1
Interferon gamma receptor 1.
   
 
 0.736
CNTFR
Ciliary neurotrophic factor receptor.
   
 
 0.735
IL11RA
Uncharacterized protein.
     
 0.712
IL13RA1
Uncharacterized protein.
   
 
 0.710
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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