node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CNTFR | IFNE | ENSSSCP00000011703 | ENSSSCP00000005523 | Ciliary neurotrophic factor receptor. | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | 0.735 |
CSF3R | IFNE | ENSSSCP00000066684 | ENSSSCP00000005523 | Granulocyte colony-stimulating factor receptor. | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | 0.821 |
DEFB112 | IFNE | ENSSSCP00000053470 | ENSSSCP00000005523 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | 0.750 |
IFNAR1 | IFNE | ENSSSCP00000067427 | ENSSSCP00000005523 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | 0.977 |
IFNAR1 | IFNGR1 | ENSSSCP00000067427 | ENSSSCP00000028797 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | Interferon gamma receptor 1. | 0.973 |
IFNAR1 | IFNGR2 | ENSSSCP00000067427 | ENSSSCP00000053061 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | Interferon gamma receptor 2 isoform 1. | 0.958 |
IFNAR1 | IL10RB | ENSSSCP00000067427 | ENSSSCP00000033998 | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | Interleukin-10 receptor subunit beta. | 0.663 |
IFNE | CNTFR | ENSSSCP00000005523 | ENSSSCP00000011703 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Ciliary neurotrophic factor receptor. | 0.735 |
IFNE | CSF3R | ENSSSCP00000005523 | ENSSSCP00000066684 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Granulocyte colony-stimulating factor receptor. | 0.821 |
IFNE | DEFB112 | ENSSSCP00000005523 | ENSSSCP00000053470 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. | 0.750 |
IFNE | IFNAR1 | ENSSSCP00000005523 | ENSSSCP00000067427 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | 0.977 |
IFNE | IFNGR1 | ENSSSCP00000005523 | ENSSSCP00000028797 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Interferon gamma receptor 1. | 0.736 |
IFNE | IFNGR2 | ENSSSCP00000005523 | ENSSSCP00000053061 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Interferon gamma receptor 2 isoform 1. | 0.766 |
IFNE | IL10RB | ENSSSCP00000005523 | ENSSSCP00000033998 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Interleukin-10 receptor subunit beta. | 0.746 |
IFNE | IL11RA | ENSSSCP00000005523 | ENSSSCP00000011697 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Uncharacterized protein. | 0.712 |
IFNE | IL13RA1 | ENSSSCP00000005523 | ENSSSCP00000013433 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Uncharacterized protein. | 0.710 |
IFNE | IL20RA | ENSSSCP00000005523 | ENSSSCP00000059834 | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | Interleukin 20 receptor subunit alpha. | 0.766 |
IFNGR1 | IFNAR1 | ENSSSCP00000028797 | ENSSSCP00000067427 | Interferon gamma receptor 1. | Interferon alpha/beta receptor 1; Component of the receptor for type I interferons, including interferons alpha, IFNB1 and IFNW1. Functions in general as heterodimer with IFNAR2. Type I interferon binding activates the JAK-STAT signaling cascade, and triggers tyrosine phosphorylation of a number of proteins including JAKs, TYK2, STAT proteins and the IFNR alpha- and beta- subunits themselves (By similarity). Can form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway (By similarity). | 0.973 |
IFNGR1 | IFNE | ENSSSCP00000028797 | ENSSSCP00000005523 | Interferon gamma receptor 1. | Interferon epsilon; Type I interferon required for maintaining basal levels of IFN-regulated genes, including 2'-5'-oligoadenylate synthetase, IRF7 and ISG15, in the female reproductive tract. Directly mediates protection against viral and bacterial genital infections (By similarity); Belongs to the alpha/beta interferon family. | 0.736 |
IFNGR1 | IFNGR2 | ENSSSCP00000028797 | ENSSSCP00000053061 | Interferon gamma receptor 1. | Interferon gamma receptor 2 isoform 1. | 0.998 |