STRINGSTRING
C5 protein (Sus scrofa) - STRING interaction network
"C5" - Complement C5a anaphylatoxin in Sus scrofa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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Gene Fusion
Cooccurence
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[Homology]
Score
C5Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation (1608 aa)    
Predicted Functional Partners:
C5AR1
Uncharacterized protein; Complement component 5a receptor 1; Belongs to the G-protein coupled receptor 1 family (351 aa)
       
  0.977
C6
Uncharacterized protein; Complement component 6 (766 aa)
     
  0.973
C5AR2
Complement component 5a receptor 2 (337 aa)
       
  0.960
C8B
Uncharacterized protein; Complement component 8, beta polypeptide (610 aa)
     
  0.956
CFB
Complement factor B; Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments- Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase; Belongs to the peptidase S1 family (765 aa)
     
  0.951
C9
Uncharacterized protein; Complement component 9 (453 aa)
     
 
  0.948
C8A
Uncharacterized protein; Complement component 8, alpha polypeptide (564 aa)
     
  0.948
CPB2
Carboxypeptidase B2 (plasma) (424 aa)
     
  0.947
C7
Complement component C7; Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells. C7 serves as a membrane anchor; Belongs to the complement C6/C7/C8/C9 family (843 aa)
     
  0.945
C2
Complement component 2; Belongs to the peptidase S1 family (752 aa)
     
  0.945
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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