STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NEK6Serine/threonine-protein kinase Nek6; Protein kinase which plays an important role in mitotic cell cycle progression. Required for chromosome segregation at metaphase- anaphase transition, robust mitotic spindle formation and cytokinesis. Phosphorylates ATF4, CIR1, PTN, RAD26L, RBBP6, RPS7, RPS6KB1, TRIP4, STAT3 and histones H1 and H3. Phosphorylates KIF11 to promote mitotic spindle formation. Involved in G2/M phase cell cycle arrest induced by DNA damage. Inhibition of activity results in apoptosis. May contribute to tumorigenesis by suppressing p53/TP53-induced cancer cell senescence [...] (402 aa)    
Predicted Functional Partners:
NEK9
NIMA related kinase 9.
    
0.899
AAR2
AAR2 splicing factor.
      
 0.794
ADGRD2
Adhesion G protein-coupled receptor D2; Belongs to the G-protein coupled receptor 2 family.
      
 0.776
ANKS6
Ankyrin repeat and SAM domain-containing protein 6 isoform X3.
    
 
 0.645
VSIG1
Uncharacterized protein.
    
 
 0.621
SAMD11
Sterile alpha motif domain containing 11.
   
  
 0.614
FRMD8
FERM domain containing 8.
      
 0.613
AP1G1
AP-1 complex subunit gamma.
      
 0.613
RCC1L
RCC1 like.
    
 
 0.591
PLEKHA8
Pleckstrin homology domain containing A8.
      
 0.577
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.