STRINGSTRING
ENG protein (Sus scrofa) - STRING interaction network
"ENG" - Endoglin in Sus scrofa
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ENGEndoglin; Vascular endothelium glycoprotein that plays an important role in the regulation of angiogenesis. Required for normal structure and integrity of adult vasculature. Regulates the migration of vascular endothelial cells (By similarity). Required for normal extraembryonic angiogenesis and for embryonic heart development (By similarity). May play a role in the binding of endothelial cells to integrins (By similarity). Acts as TGF-beta coreceptor and is involved in the TGF-beta/BMP signaling cascade that ultimately leads to the activation of SMAD transcription factors. Required fo [...] (653 aa)    
Predicted Functional Partners:
PTPRC
Protein tyrosine phosphatase, receptor type, C (689 aa)
           
  0.920
ITGB1
Integrin beta-1; Integrins alpha-1/beta-1, alpha-2/beta-1, alpha-10/beta- 1 and alpha-11/beta-1 are receptors for collagen. Integrins alpha- 1/beta-1 and alpha-2/beta-2 recognize the proline-hydroxylated sequence G-F-P-G-E-R in collagen. Integrins alpha-2/beta-1, alpha- 3/beta-1, alpha-4/beta-1, alpha-5/beta-1, alpha-8/beta-1, alpha- 10/beta-1, alpha-11/beta-1 and alpha-V/beta-1 are receptors for fibronectin. Alpha-4/beta-1 recognizes one or more domains within the alternatively spliced CS-1 and CS-5 regions of fibronectin. Integrin alpha-5/beta-1 is a receptor for fibrinogen. Integrin [...] (798 aa)
     
 
  0.920
THY1
CD90 protein; Sus scrofa Thy-1 cell surface antigen (THY1), mRNA (161 aa)
     
   
  0.913
CD34
Uncharacterized protein; CD34 molecule (401 aa)
     
   
  0.912
NT5E
5’-nucleotidase, ecto (CD73); Belongs to the 5’-nucleotidase family (574 aa)
     
   
  0.911
CD44
CD44 molecule (Indian blood group) (790 aa)
     
   
  0.874
PECAM1
Platelet endothelial cell adhesion molecule; Cell adhesion molecule which is required for leukocyte transendothelial migration (TEM) under most inflammatory conditions. Tyr-692 plays a critical role in TEM and is required for efficient trafficking of PECAM1 to and from the lateral border recycling compartment (LBRC) and is also essential for the LBRC membrane to be targeted around migrating leukocytes. Heterophilic interaction with CD177 plays a role in transendothelial migration of neutrophils. Homophilic ligation of PECAM1 prevents macrophage- mediated phagocytosis of neighboring via [...] (740 aa)
     
   
  0.866
MCAM
Melanoma cell adhesion molecule (644 aa)
     
   
  0.866
ALCAM
Activated leukocyte cell adhesion molecule (560 aa)
           
  0.864
ITGAM
Uncharacterized protein; Integrin, alpha M (complement component 3 receptor 3 subunit) (700 aa)
       
 
  0.863
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
Server load: low (23%) [HD]