Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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co-expression
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[Homology]
Score
SMPD5Endo/exonuclease/phosphatase domain-containing protein. (486 aa)    
Predicted Functional Partners:
SMPD2
Sphingomyelin phosphodiesterase 2.
     
 0.857
SMPD4
Sphingomyelin phosphodiesterase 4 isoform 2.
     
 0.856
SMPD1
Sphingomyelin phosphodiesterase; Converts sphingomyelin to ceramide.
     
 0.835
PLPP1
Phospholipid phosphatase 1; Magnesium-independent phospholipid phosphatase of the plasma membrane that catalyzes the dephosphorylation of a variety of glycerolipid and sphingolipid phosphate esters including phosphatidate/PA, lysophosphatidate/LPA, diacylglycerol pyrophosphate/DGPP, sphingosine 1-phosphate/S1P and ceramide 1- phosphate/C1P. Also acts on N- oleoyl ethanolamine phosphate/N-(9Z-octadecenoyl)-ethanolamine phosphate, a potential physiological compound (By similarity). Through its extracellular phosphatase activity allows both the hydrolysis and the cellular uptake of these [...]
     
 0.787
DEGS1
Sphingolipid delta(4)-desaturase DES1 isoform 1.
     
 0.778
UGCG
UDP-glucose ceramide glucosyltransferase.
     
 0.778
SGMS2
Phosphatidylcholine:ceramide cholinephosphotransferase 2 isoform X1.
     
 0.778
CERS4
Ceramide synthase 4.
     
 0.772
ACER2
Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.
     
 0.772
CERK
Ceramide kinase.
     
 0.752
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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