node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CRH | CRHBP | ENSSSCP00000006626 | ENSSSCP00000014985 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | 0.979 |
CRH | CRHR1 | ENSSSCP00000006626 | ENSSSCP00000018346 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | 0.997 |
CRH | CRHR2 | ENSSSCP00000006626 | ENSSSCP00000072675 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.995 |
CRH | GHRH | ENSSSCP00000006626 | ENSSSCP00000007809 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. | 0.726 |
CRH | GNRH1 | ENSSSCP00000006626 | ENSSSCP00000010305 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | GnRH-associated peptide 1; Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones; Belongs to the GnRH family. | 0.719 |
CRH | NPY | ENSSSCP00000006626 | ENSSSCP00000041417 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.864 |
CRH | OXT | ENSSSCP00000006626 | ENSSSCP00000007626 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Oxytocin-neurophysin 1; Neurophysin 1 specifically binds oxytocin. | 0.791 |
CRH | POMC | ENSSSCP00000006626 | ENSSSCP00000024582 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.922 |
CRH | TRH | ENSSSCP00000006626 | ENSSSCP00000012360 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Pro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. | 0.765 |
CRH | UCN2 | ENSSSCP00000006626 | ENSSSCP00000045074 | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | Urocortin 2. | 0.968 |
CRHBP | CRH | ENSSSCP00000014985 | ENSSSCP00000006626 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.979 |
CRHBP | CRHR1 | ENSSSCP00000014985 | ENSSSCP00000018346 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | 0.721 |
CRHBP | CRHR2 | ENSSSCP00000014985 | ENSSSCP00000072675 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.737 |
CRHBP | UCN2 | ENSSSCP00000014985 | ENSSSCP00000045074 | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | Urocortin 2. | 0.523 |
CRHR1 | CRH | ENSSSCP00000018346 | ENSSSCP00000006626 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Corticoliberin; Hormone regulating the release of corticotropin from pituitary gland. Induces NLRP6 in intestinal epithelial cells, hence may influence gut microbiota profile (By similarity); Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family. | 0.997 |
CRHR1 | CRHBP | ENSSSCP00000018346 | ENSSSCP00000014985 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Corticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. | 0.721 |
CRHR1 | CRHR2 | ENSSSCP00000018346 | ENSSSCP00000072675 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Corticotropin releasing hormone receptor 2; Belongs to the G-protein coupled receptor 2 family. | 0.902 |
CRHR1 | GHRH | ENSSSCP00000018346 | ENSSSCP00000007809 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Somatoliberin; GRF is released by the hypothalamus and acts on the adenohypophyse to stimulate the secretion of growth hormone. | 0.410 |
CRHR1 | NPY | ENSSSCP00000018346 | ENSSSCP00000041417 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.448 |
CRHR1 | POMC | ENSSSCP00000018346 | ENSSSCP00000024582 | Uncharacterized protein; Belongs to the G-protein coupled receptor 2 family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.738 |