STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
F5Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. (2258 aa)    
Predicted Functional Partners:
F2
Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity).
   
 0.989
F10
Uncharacterized protein.
   
 0.960
PROS1
Protein S.
   
 0.915
PROC
Vitamin K-dependent protein C heavy chain; Protein C is a vitamin K-dependent serine protease that regulates blood coagulation by inactivating factors Va and VIIIa in the presence of calcium ions and phospholipids. Exerts a protective effect on the endothelial cell barrier function. Belongs to the peptidase S1 family.
   
 0.848
SERPINE2
SERPIN domain-containing protein; Belongs to the serpin family.
    
 0.765
LOC100737419
Peptidase A1 domain-containing protein; Belongs to the peptidase A1 family.
    
 
 0.749
PGA5
Pepsin A; Shows particularly broad specificity; although bonds involving phenylalanine and leucine are preferred, many others are also cleaved to some extent; Belongs to the peptidase A1 family.
   
 
 0.698
F13B
Coagulation factor XIII B chain.
   
 0.662
METTL11B
Methyltransferase like 11B.
   
  
 0.656
SERPINC1
SERPIN domain-containing protein; Belongs to the serpin family.
   
 0.644
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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