| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| CFAP61 | MPZ | ENSSSCP00000042898 | ENSSSCP00000006772 | Cilia-and flagella-associated protein 61 isoform X2. | Myelin protein P0 isoform L-MPZ. | 0.610 |
| CFAP61 | RIN2 | ENSSSCP00000042898 | ENSSSCP00000026463 | Cilia-and flagella-associated protein 61 isoform X2. | Ras and Rab interactor 2. | 0.441 |
| EGR2 | MPZ | ENSSSCP00000010899 | ENSSSCP00000006772 | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. | Myelin protein P0 isoform L-MPZ. | 0.690 |
| EGR2 | SOX10 | ENSSSCP00000010899 | ENSSSCP00000035739 | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.537 |
| GJB1 | MPZ | ENSSSCP00000064594 | ENSSSCP00000006772 | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | Myelin protein P0 isoform L-MPZ. | 0.601 |
| MBP | MPZ | ENSSSCP00000061386 | ENSSSCP00000006772 | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). | Myelin protein P0 isoform L-MPZ. | 0.663 |
| MBP | NRG1 | ENSSSCP00000061386 | ENSSSCP00000042068 | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). | Neuregulin 1. | 0.604 |
| MBP | PLP1 | ENSSSCP00000061386 | ENSSSCP00000013328 | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity); Belongs to the myelin proteolipid protein family. | 0.879 |
| MBP | SOX10 | ENSSSCP00000061386 | ENSSSCP00000035739 | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.825 |
| MPZ | CFAP61 | ENSSSCP00000006772 | ENSSSCP00000042898 | Myelin protein P0 isoform L-MPZ. | Cilia-and flagella-associated protein 61 isoform X2. | 0.610 |
| MPZ | EGR2 | ENSSSCP00000006772 | ENSSSCP00000010899 | Myelin protein P0 isoform L-MPZ. | E3 SUMO-protein ligase EGR2; Sequence-specific DNA-binding transcription factor. Binds to two specific DNA sites located in the promoter region of HOXA4. Binds to the promoter region of ERBB2 (By similarity); Belongs to the EGR C2H2-type zinc-finger protein family. | 0.690 |
| MPZ | GJB1 | ENSSSCP00000006772 | ENSSSCP00000064594 | Myelin protein P0 isoform L-MPZ. | Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. | 0.601 |
| MPZ | MBP | ENSSSCP00000006772 | ENSSSCP00000061386 | Myelin protein P0 isoform L-MPZ. | Myelin basic protein; Is, with PLP, the most abundant protein component of the myelin membrane in the CNS. Has a role in both the formation and stabilization of this compact multilayer arrangement of bilayers. Each splice variant and charge isomer may have a specialized function in the assembly of an optimized, biochemically functional myelin membrane (By similarity). | 0.663 |
| MPZ | MPZL1 | ENSSSCP00000006772 | ENSSSCP00000006723 | Myelin protein P0 isoform L-MPZ. | Myelin protein zero like 1. | 0.900 |
| MPZ | NRG1 | ENSSSCP00000006772 | ENSSSCP00000042068 | Myelin protein P0 isoform L-MPZ. | Neuregulin 1. | 0.643 |
| MPZ | PLP1 | ENSSSCP00000006772 | ENSSSCP00000013328 | Myelin protein P0 isoform L-MPZ. | Myelin proteolipid protein; This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin (By similarity); Belongs to the myelin proteolipid protein family. | 0.597 |
| MPZ | RIN2 | ENSSSCP00000006772 | ENSSSCP00000026463 | Myelin protein P0 isoform L-MPZ. | Ras and Rab interactor 2. | 0.602 |
| MPZ | SH3TC2 | ENSSSCP00000006772 | ENSSSCP00000042548 | Myelin protein P0 isoform L-MPZ. | SH3 domain and tetratricopeptide repeats 2. | 0.632 |
| MPZ | SOX10 | ENSSSCP00000006772 | ENSSSCP00000035739 | Myelin protein P0 isoform L-MPZ. | Transcription factor SOX-10; Transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (By similarity). | 0.565 |
| MPZL1 | MPZ | ENSSSCP00000006723 | ENSSSCP00000006772 | Myelin protein zero like 1. | Myelin protein P0 isoform L-MPZ. | 0.900 |