STRINGSTRING
S100A12 protein (Sus scrofa) - STRING interaction network
"S100A12" - Protein S100-A12 in Sus scrofa
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
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S100A12Protein S100-A12; S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leadin [...] (92 aa)    
Predicted Functional Partners:
AGER
Sus scrofa advanced glycosylation end product-specific receptor (AGER), mRNA (404 aa)
     
  0.980
S100A8
Protein S100-A8 ; Belongs to the S-100 family (89 aa)
     
 
0.949
S100B
S100 calcium binding protein B; Belongs to the S-100 family (92 aa)
       
0.910
RELA
NF-kappaB transcription factor p65 subunit; Sus scrofa v-rel reticuloendotheliosis viral oncogene homolog A (avian) (RELA), mRNA (553 aa)
         
  0.910
NFKB1
Uncharacterized protein; Sus scrofa nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 (NFKB1), mRNA (80 aa)
         
  0.908
NFKB2_TV2
Nuclear factor kappa B subunit 2 (865 aa)
         
  0.902
CAPZA1
Capping protein (Actin filament) muscle Z-line, alpha 1; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (214 aa)
         
  0.902
ENSSSCG00000027479
Uncharacterized protein (504 aa)
         
    0.900
S100A9
Sus scrofa S100 calcium binding protein A9 (S100A9), mRNA; Belongs to the S-100 family (144 aa)
     
   
0.826
S100A2
S100 calcium binding protein A2; Belongs to the S-100 family (140 aa)
     
   
  0.593
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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