STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
VPS45Uncharacterized protein; Belongs to the STXBP/unc-18/SEC1 family. (570 aa)    
Predicted Functional Partners:
RBSN
Rabenosyn, RAB effector.
    
 0.997
STX16-NPEPL1
t-SNARE coiled-coil homology domain-containing protein; Belongs to the syntaxin family.
    
 
 0.978
MTO1
Mitochondrial tRNA translation optimization 1.
 
      0.900
ERGIC3
ERGIC and golgi 3.
 
      0.900
VTI1A
Vesicle transport through interaction with t-SNAREs 1A.
   
 
 0.890
RAB5A
Ras-related protein Rab-5A; Small GTPase which cycles between active GTP-bound and inactive GDP-bound states. In its active state, binds to a variety of effector proteins to regulate cellular responses such as of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Active GTP-bound form is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. RAB5A is required for the fusion of plasma membranes and early endosomes. Contributes to the regulati [...]
    
 0.888
COG6
Conserved oligomeric Golgi complex subunit 6; Required for normal Golgi function.
    
 0.842
STX6
Syntaxin 6; Belongs to the syntaxin family.
    
 
 0.827
VTI1B
t-SNARE coiled-coil homology domain-containing protein.
   
 
 0.804
COG3
Component of oligomeric golgi complex 3; Belongs to the mitochondrial carrier (TC 2.A.29) family.
     
 0.803
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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