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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
NGFNerve growth factor, beta; Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone coll [...] (241 aa)    
Predicted Functional Partners:
NTRK1
Neurotrophic tyrosine kinase, receptor, type 1
    
 0.997
NGFR
Tumor necrosis factor receptor superfamily member 16; Nerve growth factor receptor
    
 0.984
NTRK2
annotation not available
    
 0.948
SORT1
Sortilin isoform x3; Sortilin
    
 0.903
NTRK3
Neurotrophic tyrosine kinase, receptor type 3; Receptor tyrosine kinase involved in nervous system and probably heart development. Upon binding of its ligand NTF3/neurotrophin-3, NTRK3 autophosphorylates and activates different signaling pathways, including the phosphatidylinositol 3-kinase/AKT and the MAPK pathways, that control cell survival and differentiation
    
 0.894
ENSSSCP00000023481
Uncharacterized protein
    
 0.824
ENSSSCP00000027555
Tyrosine-protein kinase receptor
    
 0.824
SORCS2
annotation not available
   
 0.772
ENSSSCP00000009293
annotation not available
   
 0.772
SHC1
Shc-transforming protein 1 isoform x2; SHC adaptor protein 1; SHC (Src homology 2 domain containing) transforming protein 1
     
 0.758
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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