BCL2L1 protein (Sus scrofa) - STRING interaction network

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BCL2L1

Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...] (233 aa)

Predicted Functional Partners:

BCL2L11

0.998

BAD

0.998

BID

0.997

BAK1

0.996

BBC3

0.996

PMAIP1

0.995

BECN1

0.991

TP53

0.989

BECN2

0.983

CASP9

0.977

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BAD	BAK1	ENSSSCP00000042395	ENSSSCP00000032742	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.733
BAD	BCL2L1	ENSSSCP00000042395	ENSSSCP00000033436	BCL2 associated agonist of cell death.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.998
BAD	BCL2L11	ENSSSCP00000042395	ENSSSCP00000008657	BCL2 associated agonist of cell death.	Uncharacterized protein.	0.921
BAD	BID	ENSSSCP00000042395	ENSSSCP00000048980	BCL2 associated agonist of cell death.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.914
BAD	CASP9	ENSSSCP00000042395	ENSSSCP00000003758	BCL2 associated agonist of cell death.	Caspase 9; Belongs to the peptidase C14A family.	0.521
BAD	TP53	ENSSSCP00000042395	ENSSSCP00000050664	BCL2 associated agonist of cell death.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.469
BAK1	BAD	ENSSSCP00000032742	ENSSSCP00000042395	Uncharacterized protein.	BCL2 associated agonist of cell death.	0.733
BAK1	BBC3	ENSSSCP00000032742	ENSSSCP00000070559	Uncharacterized protein.	Uncharacterized protein.	0.686
BAK1	BCL2L1	ENSSSCP00000032742	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.996
BAK1	BCL2L11	ENSSSCP00000032742	ENSSSCP00000008657	Uncharacterized protein.	Uncharacterized protein.	0.962
BAK1	BECN1	ENSSSCP00000032742	ENSSSCP00000018420	Uncharacterized protein.	Beclin-1-C 35 kDa; Plays a central role in autophagy. Acts as core subunit of the PI3K complex that mediates formation of phosphatidylinositol 3- phosphate; different complex forms are believed to play a role in multiple membrane trafficking pathways: PI3KC3-C1 is involved in initiation of autophagosomes and PI3KC3-C2 in maturation of autophagosomes and endocytosis. Involved in regulation of degradative endocytic trafficking and required for the abcission step in cytokinesis, probably in the context of PI3KC3-C2. Essential for the formation of PI3KC3-C2 but not PI3KC3-C1 PI3K complex f [...]	0.597
BAK1	BECN2	ENSSSCP00000032742	ENSSSCP00000011586	Uncharacterized protein.	Beclin 2.	0.500
BAK1	BID	ENSSSCP00000032742	ENSSSCP00000048980	Uncharacterized protein.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.999
BAK1	CASP9	ENSSSCP00000032742	ENSSSCP00000003758	Uncharacterized protein.	Caspase 9; Belongs to the peptidase C14A family.	0.700
BAK1	PMAIP1	ENSSSCP00000032742	ENSSSCP00000027713	Uncharacterized protein.	Uncharacterized protein.	0.726
BAK1	TP53	ENSSSCP00000032742	ENSSSCP00000050664	Uncharacterized protein.	Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...]	0.997
BBC3	BAK1	ENSSSCP00000070559	ENSSSCP00000032742	Uncharacterized protein.	Uncharacterized protein.	0.686
BBC3	BCL2L1	ENSSSCP00000070559	ENSSSCP00000033436	Uncharacterized protein.	Bcl-2-like protein 1; Potent inhibitor of cell death. Inhibits activation of caspases. Appears to regulate cell death by blocking the voltage- dependent anion channel (VDAC) by binding to it and preventing the release of the caspase activator, CYC1, from the mitochondrial membrane. Also acts as a regulator of G2 checkpoint and progression to cytokinesis during mitosis. Regulates presynaptic plasticity, including neurotransmitter release and recovery, number of axonal mitochondria as well as size and number of synaptic vesicle clusters. During synaptic stimulation, increases ATP availab [...]	0.996
BBC3	BCL2L11	ENSSSCP00000070559	ENSSSCP00000008657	Uncharacterized protein.	Uncharacterized protein.	0.954
BBC3	BID	ENSSSCP00000070559	ENSSSCP00000048980	Uncharacterized protein.	BH3-interacting domain death agonist p11; Induces caspases and apoptosis. Counters the protective effect of Bcl-2. The major proteolytic product p15 BID allows the release of cytochrome c (By similarity).	0.926

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