node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
EIF3A | EIF4E | ENSSSCP00000011378 | ENSSSCP00000027266 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | 0.422 |
EIF3A | EIF4G1 | ENSSSCP00000011378 | ENSSSCP00000052793 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Eukaryotic translation initiation factor 4 gamma 1. | 0.720 |
EIF3A | EIF4G2 | ENSSSCP00000011378 | ENSSSCP00000014250 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Eukaryotic translation initiation factor 4 gamma 2. | 0.660 |
EIF3A | EIF4G3 | ENSSSCP00000011378 | ENSSSCP00000042484 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Eukaryotic translation initiation factor 4 gamma 3. | 0.677 |
EIF3A | GSPT2 | ENSSSCP00000011378 | ENSSSCP00000013108 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | G1 to S phase transition 2. | 0.584 |
EIF3A | PABPC1L | ENSSSCP00000011378 | ENSSSCP00000007865 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. | 0.685 |
EIF3A | PAIP1 | ENSSSCP00000011378 | ENSSSCP00000043450 | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | Poly(A) binding protein interacting protein 1. | 0.720 |
EIF4E | EIF3A | ENSSSCP00000027266 | ENSSSCP00000011378 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | 0.422 |
EIF4E | EIF4G1 | ENSSSCP00000027266 | ENSSSCP00000052793 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Eukaryotic translation initiation factor 4 gamma 1. | 0.995 |
EIF4E | EIF4G2 | ENSSSCP00000027266 | ENSSSCP00000014250 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Eukaryotic translation initiation factor 4 gamma 2. | 0.990 |
EIF4E | EIF4G3 | ENSSSCP00000027266 | ENSSSCP00000042484 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Eukaryotic translation initiation factor 4 gamma 3. | 0.960 |
EIF4E | PABPC1L | ENSSSCP00000027266 | ENSSSCP00000007865 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. | 0.848 |
EIF4E | PAIP1 | ENSSSCP00000027266 | ENSSSCP00000043450 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | Poly(A) binding protein interacting protein 1. | 0.967 |
EIF4E | PAN3 | ENSSSCP00000027266 | ENSSSCP00000009944 | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] | 0.475 |
EIF4G1 | EIF3A | ENSSSCP00000052793 | ENSSSCP00000011378 | Eukaryotic translation initiation factor 4 gamma 1. | Eukaryotic translation initiation factor 3 subunit A; RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termi [...] | 0.720 |
EIF4G1 | EIF4E | ENSSSCP00000052793 | ENSSSCP00000027266 | Eukaryotic translation initiation factor 4 gamma 1. | Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. | 0.995 |
EIF4G1 | EIF4G2 | ENSSSCP00000052793 | ENSSSCP00000014250 | Eukaryotic translation initiation factor 4 gamma 1. | Eukaryotic translation initiation factor 4 gamma 2. | 0.953 |
EIF4G1 | EIF4G3 | ENSSSCP00000052793 | ENSSSCP00000042484 | Eukaryotic translation initiation factor 4 gamma 1. | Eukaryotic translation initiation factor 4 gamma 3. | 0.542 |
EIF4G1 | GSPT2 | ENSSSCP00000052793 | ENSSSCP00000013108 | Eukaryotic translation initiation factor 4 gamma 1. | G1 to S phase transition 2. | 0.497 |
EIF4G1 | PABPC1L | ENSSSCP00000052793 | ENSSSCP00000007865 | Eukaryotic translation initiation factor 4 gamma 1. | Polyadenylate-binding protein; Binds the poly(A) tail of mRNA. Belongs to the polyadenylate-binding protein type-1 family. | 0.722 |