BRAT1 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

BRAT1

BRCA1-associated ATM activator 1 isoform 2. (822 aa)

Predicted Functional Partners:

BRCA1

0.682

TONSL

0.586

E4F1

0.549

POLA1

0.519

CDKN2D

0.518

CDK12

0.518

DSCC1

0.514

TP53BP1

0.510

INCA1

0.503

SDCBP

0.501

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRAT1	BRCA1	ENSSSCP00000008076	ENSSSCP00000034439	BRCA1-associated ATM activator 1 isoform 2.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.682
BRAT1	CDK12	ENSSSCP00000008076	ENSSSCP00000055304	BRCA1-associated ATM activator 1 isoform 2.	Cyclin dependent kinase 12.	0.518
BRAT1	CDKN2D	ENSSSCP00000008076	ENSSSCP00000033946	BRCA1-associated ATM activator 1 isoform 2.	Cyclin dependent kinase inhibitor 2D.	0.518
BRAT1	DSCC1	ENSSSCP00000008076	ENSSSCP00000045039	BRCA1-associated ATM activator 1 isoform 2.	DNA replication and sister chromatid cohesion 1.	0.514
BRAT1	E4F1	ENSSSCP00000008076	ENSSSCP00000064472	BRCA1-associated ATM activator 1 isoform 2.	E4F transcription factor 1.	0.549
BRAT1	INCA1	ENSSSCP00000008076	ENSSSCP00000069277	BRCA1-associated ATM activator 1 isoform 2.	Uncharacterized protein.	0.503
BRAT1	POLA1	ENSSSCP00000008076	ENSSSCP00000072012	BRCA1-associated ATM activator 1 isoform 2.	DNA polymerase.	0.519
BRAT1	SDCBP	ENSSSCP00000008076	ENSSSCP00000072922	BRCA1-associated ATM activator 1 isoform 2.	Syndecan binding protein.	0.501
BRAT1	TONSL	ENSSSCP00000008076	ENSSSCP00000024391	BRCA1-associated ATM activator 1 isoform 2.	Tonsoku like, DNA repair protein.	0.586
BRAT1	TP53BP1	ENSSSCP00000008076	ENSSSCP00000037159	BRCA1-associated ATM activator 1 isoform 2.	Tumor protein p53 binding protein 1.	0.510
BRCA1	BRAT1	ENSSSCP00000034439	ENSSSCP00000008076	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	BRCA1-associated ATM activator 1 isoform 2.	0.682
BRCA1	CDK12	ENSSSCP00000034439	ENSSSCP00000055304	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Cyclin dependent kinase 12.	0.561
BRCA1	TP53BP1	ENSSSCP00000034439	ENSSSCP00000037159	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	Tumor protein p53 binding protein 1.	0.907
CDK12	BRAT1	ENSSSCP00000055304	ENSSSCP00000008076	Cyclin dependent kinase 12.	BRCA1-associated ATM activator 1 isoform 2.	0.518
CDK12	BRCA1	ENSSSCP00000055304	ENSSSCP00000034439	Cyclin dependent kinase 12.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.561
CDKN2D	BRAT1	ENSSSCP00000033946	ENSSSCP00000008076	Cyclin dependent kinase inhibitor 2D.	BRCA1-associated ATM activator 1 isoform 2.	0.518
CDKN2D	INCA1	ENSSSCP00000033946	ENSSSCP00000069277	Cyclin dependent kinase inhibitor 2D.	Uncharacterized protein.	0.483
DSCC1	BRAT1	ENSSSCP00000045039	ENSSSCP00000008076	DNA replication and sister chromatid cohesion 1.	BRCA1-associated ATM activator 1 isoform 2.	0.514
DSCC1	POLA1	ENSSSCP00000045039	ENSSSCP00000072012	DNA replication and sister chromatid cohesion 1.	DNA polymerase.	0.808
DSCC1	TONSL	ENSSSCP00000045039	ENSSSCP00000024391	DNA replication and sister chromatid cohesion 1.	Tonsoku like, DNA repair protein.	0.547