| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACTB | ACTG1 | ENSSSCP00000035521 | ENSSSCP00000040911 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Actin gamma 1. | 0.992 |
| ACTB | MYH11 | ENSSSCP00000035521 | ENSSSCP00000051394 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Myosin-11; Muscle contraction. | 0.950 |
| ACTB | MYL10 | ENSSSCP00000035521 | ENSSSCP00000008202 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Myosin light chain 10. | 0.929 |
| ACTB | MYL6 | ENSSSCP00000035521 | ENSSSCP00000060677 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. | 0.951 |
| ACTB | PPP1CA | ENSSSCP00000035521 | ENSSSCP00000032273 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.526 |
| ACTB | ROCK1 | ENSSSCP00000035521 | ENSSSCP00000063816 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. | 0.532 |
| ACTB | ROCK2 | ENSSSCP00000035521 | ENSSSCP00000060082 | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | Rho-associated protein kinase 2; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of ADD1, BRCA2, CNN1, EZR, DPYSL2, EP300, MSN, MYL9/MLC2, NPM1, RDX, PPP1R12A and VIM. Phosphorylates SORL1 and IRF4. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Positively regulates the activation of p42/MAPK1- p44/MAPK3 and of p90RSK/RPS6K [...] | 0.430 |
| ACTG1 | ACTB | ENSSSCP00000040911 | ENSSSCP00000035521 | Actin gamma 1. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.992 |
| ACTG1 | MYH11 | ENSSSCP00000040911 | ENSSSCP00000051394 | Actin gamma 1. | Myosin-11; Muscle contraction. | 0.943 |
| ACTG1 | MYL10 | ENSSSCP00000040911 | ENSSSCP00000008202 | Actin gamma 1. | Myosin light chain 10. | 0.929 |
| ACTG1 | MYL6 | ENSSSCP00000040911 | ENSSSCP00000060677 | Actin gamma 1. | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. | 0.944 |
| ACTG1 | PPP1CA | ENSSSCP00000040911 | ENSSSCP00000032273 | Actin gamma 1. | Serine/threonine-protein phosphatase; Belongs to the PPP phosphatase family. | 0.452 |
| MYH11 | ACTB | ENSSSCP00000051394 | ENSSSCP00000035521 | Myosin-11; Muscle contraction. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.950 |
| MYH11 | ACTG1 | ENSSSCP00000051394 | ENSSSCP00000040911 | Myosin-11; Muscle contraction. | Actin gamma 1. | 0.943 |
| MYH11 | MYL10 | ENSSSCP00000051394 | ENSSSCP00000008202 | Myosin-11; Muscle contraction. | Myosin light chain 10. | 0.905 |
| MYH11 | MYL6 | ENSSSCP00000051394 | ENSSSCP00000060677 | Myosin-11; Muscle contraction. | Myosin light polypeptide 6; Regulatory light chain of myosin. Does not bind calcium. | 0.978 |
| MYH11 | MYLK | ENSSSCP00000051394 | ENSSSCP00000040501 | Myosin-11; Muscle contraction. | Myosin light chain kinase, smooth muscle; Phosphorylates a specific serine in the N-terminus of a myosin light chain. Also regulates actin-myosin interaction through a non-kinase activity (By similarity). | 0.645 |
| MYL10 | ACTB | ENSSSCP00000008202 | ENSSSCP00000035521 | Myosin light chain 10. | Actin, cytoplasmic 1, N-terminally processed; Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. | 0.929 |
| MYL10 | ACTG1 | ENSSSCP00000008202 | ENSSSCP00000040911 | Myosin light chain 10. | Actin gamma 1. | 0.929 |
| MYL10 | MYH11 | ENSSSCP00000008202 | ENSSSCP00000051394 | Myosin light chain 10. | Myosin-11; Muscle contraction. | 0.905 |
