STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TRIM50E3 ubiquitin-protein ligase TRIM50; E3 ubiquitin-protein ligase that ubiquitinates Beclin-1/BECN1 in a 'Lys-63'-dependent manner enhancing its binding to ULK1. In turn, promotes starvation-induced autophagy activation. Interacts also with p62/SQSTM1 protein and thereby induces the formation and the autophagy clearance of aggresome-associated polyubiquitinated proteins through HDAC6 interaction; Belongs to the TRIM/RBCC family. (486 aa)    
Predicted Functional Partners:
NBAS
Neuroblastoma amplified sequence.
    
 
 0.650
TRIM23
E3 ubiquitin-protein ligase TRIM23 isoform alpha.
    
 
 0.610
FKBP6
Peptidylprolyl isomerase.
    
 
 0.522
KIAA1549L
KIAA1549 like.
      
 0.514
TRIM44
Tripartite motif containing 44.
    
 
 0.509
TRIM67
Tripartite motif containing 67.
   
  
 0.507
PAQR9
Progestin and adipoQ receptor family member 9.
   
  
 0.505
EXOSC6
Exosome component 6.
      
 0.503
FAM89A
Family with sequence similarity 89 member A.
      
 0.503
NOS1AP
PID domain-containing protein.
      
 0.501
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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