PHKG2 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

PHKG2

Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily. (406 aa)

Predicted Functional Partners:

PHKA1

0.999

PHKB

0.999

PHKA2

0.999

PHKG1

0.984

PYGL

0.937

CALML4

0.937

CALML5

0.929

PRKACA

0.899

PRKACB

0.899

PYGB

0.896

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CALML4	CALML5	ENSSSCP00000071054	ENSSSCP00000011880	Uncharacterized protein.	Calmodulin like 5.	0.865
CALML4	PHKA1	ENSSSCP00000071054	ENSSSCP00000013207	Uncharacterized protein.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.928
CALML4	PHKA2	ENSSSCP00000071054	ENSSSCP00000051742	Uncharacterized protein.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.927
CALML4	PHKB	ENSSSCP00000071054	ENSSSCP00000042929	Uncharacterized protein.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.927
CALML4	PHKG1	ENSSSCP00000071054	ENSSSCP00000008272	Uncharacterized protein.	Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily.	0.941
CALML4	PHKG2	ENSSSCP00000071054	ENSSSCP00000008317	Uncharacterized protein.	Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily.	0.937
CALML4	PRKACA	ENSSSCP00000071054	ENSSSCP00000035101	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.983
CALML4	PRKACB	ENSSSCP00000071054	ENSSSCP00000058922	Uncharacterized protein.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.983
CALML4	PYGB	ENSSSCP00000071054	ENSSSCP00000069286	Uncharacterized protein.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.915
CALML4	PYGL	ENSSSCP00000071054	ENSSSCP00000044663	Uncharacterized protein.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.912
CALML5	CALML4	ENSSSCP00000011880	ENSSSCP00000071054	Calmodulin like 5.	Uncharacterized protein.	0.865
CALML5	PHKA1	ENSSSCP00000011880	ENSSSCP00000013207	Calmodulin like 5.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.949
CALML5	PHKA2	ENSSSCP00000011880	ENSSSCP00000051742	Calmodulin like 5.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I.	0.928
CALML5	PHKB	ENSSSCP00000011880	ENSSSCP00000042929	Calmodulin like 5.	Phosphorylase b kinase regulatory subunit; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. Belongs to the phosphorylase b kinase regulatory chain family.	0.949
CALML5	PHKG1	ENSSSCP00000011880	ENSSSCP00000008272	Calmodulin like 5.	Phosphorylase kinase gamma 1; Belongs to the protein kinase superfamily.	0.943
CALML5	PHKG2	ENSSSCP00000011880	ENSSSCP00000008317	Calmodulin like 5.	Phosphorylase kinase catalytic subunit gamma 2; Belongs to the protein kinase superfamily.	0.929
CALML5	PRKACA	ENSSSCP00000011880	ENSSSCP00000035101	Calmodulin like 5.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.976
CALML5	PRKACB	ENSSSCP00000011880	ENSSSCP00000058922	Calmodulin like 5.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.976
CALML5	PYGB	ENSSSCP00000011880	ENSSSCP00000069286	Calmodulin like 5.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.926
CALML5	PYGL	ENSSSCP00000011880	ENSSSCP00000044663	Calmodulin like 5.	Alpha-1,4 glucan phosphorylase; Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties.	0.926