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IL4R protein (Sus scrofa) - STRING interaction network
"IL4R" - Interleukin-4 receptor subunit alpha in Sus scrofa
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Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
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textmining
co-expression
protein homology
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IL4RInterleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity) (807 aa)    
Predicted Functional Partners:
IL13
Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages (131 aa)
       
  0.994
IL4
Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages (133 aa)
       
  0.993
IL13RA1
Sus scrofa interleukin 13 receptor, alpha 1 (IL13RA1), mRNA (423 aa)
     
  0.989
IL2RG
Uncharacterized protein; Sus scrofa interleukin 2 receptor, gamma (IL2RG), mRNA (368 aa)
     
  0.988
JAK1
Janus kinase 1 (330 aa)
     
  0.968
ENSSSCG00000026524
Sus scrofa signal transducer and activator of transcription 6, interleukin-4 induced (STAT6), mRNA (848 aa)
     
  0.957
SOCS5
Sus scrofa suppressor of cytokine signaling 5 (SOCS5), mRNA (536 aa)
       
  0.956
JAK3
Janus kinase 3 (1104 aa)
     
  0.950
JAK2
Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN-beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors, [...] (1095 aa)
     
  0.932
SOCS1
Sus scrofa suppressor of cytokine signaling 1 (SOCS1), mRNA (220 aa)
     
  0.928
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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