node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
IL13 | IL13RA1 | ENSSSCP00000030285 | ENSSSCP00000013433 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Uncharacterized protein. | 0.992 |
IL13 | IL13RA2 | ENSSSCP00000030285 | ENSSSCP00000030515 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin 13 receptor subunit alpha 2. | 0.993 |
IL13 | IL2RG | ENSSSCP00000030285 | ENSSSCP00000013192 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Cytokine receptor common subunit gamma. | 0.650 |
IL13 | IL4 | ENSSSCP00000030285 | ENSSSCP00000015193 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.991 |
IL13 | IL4R | ENSSSCP00000030285 | ENSSSCP00000008346 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.993 |
IL13 | IL9 | ENSSSCP00000030285 | ENSSSCP00000019202 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Uncharacterized protein. | 0.899 |
IL13 | JAK1 | ENSSSCP00000030285 | ENSSSCP00000032415 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Tyrosine-protein kinase. | 0.475 |
IL13 | JAK2 | ENSSSCP00000030285 | ENSSSCP00000029236 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.423 |
IL13 | STAT6 | ENSSSCP00000030285 | ENSSSCP00000019659 | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | Signal transducer and activator of transcription. | 0.943 |
IL13RA1 | IL13 | ENSSSCP00000013433 | ENSSSCP00000030285 | Uncharacterized protein. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.992 |
IL13RA1 | IL13RA2 | ENSSSCP00000013433 | ENSSSCP00000030515 | Uncharacterized protein. | Interleukin 13 receptor subunit alpha 2. | 0.465 |
IL13RA1 | IL4 | ENSSSCP00000013433 | ENSSSCP00000015193 | Uncharacterized protein. | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] | 0.990 |
IL13RA1 | IL4R | ENSSSCP00000013433 | ENSSSCP00000008346 | Uncharacterized protein. | Interleukin-4 receptor subunit alpha; Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2 (By similarity). | 0.948 |
IL13RA1 | IL9 | ENSSSCP00000013433 | ENSSSCP00000019202 | Uncharacterized protein. | Uncharacterized protein. | 0.682 |
IL13RA1 | JAK1 | ENSSSCP00000013433 | ENSSSCP00000032415 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.834 |
IL13RA1 | JAK2 | ENSSSCP00000013433 | ENSSSCP00000029236 | Uncharacterized protein. | Tyrosine-protein kinase JAK2; Non-receptor tyrosine kinase involved in various processes such as cell growth, development, differentiation or histone modifications. Mediates essential signaling events in both innate and adaptive immunity. In the cytoplasm, plays a pivotal role in signal transduction via its association with type I receptors such as growth hormone (GHR), prolactin (PRLR), leptin (LEPR), erythropoietin (EPOR), thrombopoietin (THPO); or type II receptors including IFN-alpha, IFN- beta, IFN-gamma and multiple interleukins. Following ligand-binding to cell surface receptors [...] | 0.842 |
IL13RA1 | JAK3 | ENSSSCP00000013433 | ENSSSCP00000030830 | Uncharacterized protein. | Tyrosine-protein kinase. | 0.759 |
IL13RA1 | STAT6 | ENSSSCP00000013433 | ENSSSCP00000019659 | Uncharacterized protein. | Signal transducer and activator of transcription. | 0.722 |
IL13RA2 | IL13 | ENSSSCP00000030515 | ENSSSCP00000030285 | Interleukin 13 receptor subunit alpha 2. | Interleukin-13; Cytokine. Inhibits inflammatory cytokine production. Synergizes with IL2 in regulating interferon-gamma synthesis. May be critical in regulating inflammatory and immune responses. Positively regulates IL31RA expression in macrophages. | 0.993 |
IL13RA2 | IL13RA1 | ENSSSCP00000030515 | ENSSSCP00000013433 | Interleukin 13 receptor subunit alpha 2. | Uncharacterized protein. | 0.465 |