node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
FASLG | GNLY | ENSSSCP00000019767 | ENSSSCP00000068499 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | 0.710 |
FASLG | GZMA | ENSSSCP00000019767 | ENSSSCP00000017911 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Granzyme A; Belongs to the peptidase S1 family. | 0.658 |
FASLG | GZMA-2 | ENSSSCP00000019767 | ENSSSCP00000017912 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.674 |
FASLG | GZMB | ENSSSCP00000019767 | ENSSSCP00000069304 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.511 |
FASLG | KLRD1 | ENSSSCP00000019767 | ENSSSCP00000074449 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Killer cell lectin like receptor D1. | 0.477 |
FASLG | PRF1 | ENSSSCP00000019767 | ENSSSCP00000049598 | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | Perforin 1. | 0.777 |
GNLY | FASLG | ENSSSCP00000068499 | ENSSSCP00000019767 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | 0.710 |
GNLY | GZMA | ENSSSCP00000068499 | ENSSSCP00000017911 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Granzyme A; Belongs to the peptidase S1 family. | 0.925 |
GNLY | GZMA-2 | ENSSSCP00000068499 | ENSSSCP00000017912 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.927 |
GNLY | GZMB | ENSSSCP00000068499 | ENSSSCP00000069304 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.714 |
GNLY | GZMK | ENSSSCP00000068499 | ENSSSCP00000017909 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Granzyme K; Belongs to the peptidase S1 family. | 0.714 |
GNLY | KLRD1 | ENSSSCP00000068499 | ENSSSCP00000074449 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Killer cell lectin like receptor D1. | 0.706 |
GNLY | NKG7 | ENSSSCP00000068499 | ENSSSCP00000003507 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Uncharacterized protein. | 0.828 |
GNLY | PRF1 | ENSSSCP00000068499 | ENSSSCP00000049598 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Perforin 1. | 0.837 |
GNLY | PSAP | ENSSSCP00000068499 | ENSSSCP00000035634 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Saposin-B-Val; Saposin-B stimulates the hydrolysis of galacto-cerebroside sulfate by arylsulfatase A (EC 3.1.6.8), GM1 gangliosides by beta- galactosidase (EC 3.2.1.23) and globotriaosylceramide by alpha- galactosidase A (EC 3.2.1.22). Saposin-B forms a solubilizing complex with the substrates of the sphingolipid hydrolases. | 0.689 |
GNLY | PSAPL1 | ENSSSCP00000068499 | ENSSSCP00000009288 | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | Proactivator polypeptide-like 1; May activate the lysosomal degradation of sphingolipids. | 0.801 |
GZMA | FASLG | ENSSSCP00000017911 | ENSSSCP00000019767 | Granzyme A; Belongs to the peptidase S1 family. | Tumor necrosis factor ligand superfamily member 6, membrane form; Cytokine that binds to TNFRSF6/FAS, a receptor that transduces the apoptotic signal into cells. Involved in cytotoxic T-cell-mediated apoptosis, natural killer cell-mediated apoptosis and in T-cell development. Initiates fratricidal/suicidal activation-induced cell death (AICD) in antigen-activated T-cells contributing to the termination of immune responses (By similarity). TNFRSF6/FAS-mediated apoptosis has also a role in the induction of peripheral tolerance (By similarity). Binds to TNFRSF6B/DcR3, a decoy receptor tha [...] | 0.658 |
GZMA | GNLY | ENSSSCP00000017911 | ENSSSCP00000068499 | Granzyme A; Belongs to the peptidase S1 family. | Antimicrobial peptide NK-lysin; May be an effector molecule of cytotoxic activity. High activity against E.coli and B.megaterium, moderate against A.calcoaceticus and S.pyogenes. No activity against P.aeruginosa, S.aureus and Salmonella. Has some antifungal activity against C.albicans. | 0.925 |
GZMA | GZMB | ENSSSCP00000017911 | ENSSSCP00000069304 | Granzyme A; Belongs to the peptidase S1 family. | Peptidase S1 domain-containing protein; Belongs to the peptidase S1 family. | 0.416 |
GZMA | GZMK | ENSSSCP00000017911 | ENSSSCP00000017909 | Granzyme A; Belongs to the peptidase S1 family. | Granzyme K; Belongs to the peptidase S1 family. | 0.440 |