PRKCE protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:

Neighborhood

Gene Fusion

Cooccurrence

Coexpression

Experiments

Databases

Textmining

[Homology]

Score

PRKCE

Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)

Predicted Functional Partners:

GNB2

0.936

GNG10

0.930

PPP1CC

0.929

GNAI3

0.925

GNB5

0.923

MAPK10

0.922

TRPV1

0.919

RRAS

0.917

TRPA1

0.917

RRAS2

0.917

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
GNAI3	GNB2	ENSSSCP00000007279	ENSSSCP00000008190	Guanine nucleotide-binding protein G(K) subunit alpha.	G protein subunit beta 2.	0.927
GNAI3	GNB5	ENSSSCP00000007279	ENSSSCP00000031679	Guanine nucleotide-binding protein G(K) subunit alpha.	G protein subunit beta 5.	0.816
GNAI3	GNG10	ENSSSCP00000007279	ENSSSCP00000072165	Guanine nucleotide-binding protein G(K) subunit alpha.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.759
GNAI3	MAPK10	ENSSSCP00000007279	ENSSSCP00000029707	Guanine nucleotide-binding protein G(K) subunit alpha.	Mitogen-activated protein kinase.	0.663
GNAI3	PRKCE	ENSSSCP00000007279	ENSSSCP00000009012	Guanine nucleotide-binding protein G(K) subunit alpha.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.925
GNB2	GNAI3	ENSSSCP00000008190	ENSSSCP00000007279	G protein subunit beta 2.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.927
GNB2	GNB5	ENSSSCP00000008190	ENSSSCP00000031679	G protein subunit beta 2.	G protein subunit beta 5.	0.601
GNB2	GNG10	ENSSSCP00000008190	ENSSSCP00000072165	G protein subunit beta 2.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.884
GNB2	MAPK10	ENSSSCP00000008190	ENSSSCP00000029707	G protein subunit beta 2.	Mitogen-activated protein kinase.	0.650
GNB2	PRKCE	ENSSSCP00000008190	ENSSSCP00000009012	G protein subunit beta 2.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.936
GNB2	RRAS	ENSSSCP00000008190	ENSSSCP00000003452	G protein subunit beta 2.	RAS related.	0.705
GNB2	RRAS2	ENSSSCP00000008190	ENSSSCP00000038357	G protein subunit beta 2.	Uncharacterized protein.	0.691
GNB5	GNAI3	ENSSSCP00000031679	ENSSSCP00000007279	G protein subunit beta 5.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.816
GNB5	GNB2	ENSSSCP00000031679	ENSSSCP00000008190	G protein subunit beta 5.	G protein subunit beta 2.	0.601
GNB5	GNG10	ENSSSCP00000031679	ENSSSCP00000072165	G protein subunit beta 5.	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	0.720
GNB5	MAPK10	ENSSSCP00000031679	ENSSSCP00000029707	G protein subunit beta 5.	Mitogen-activated protein kinase.	0.654
GNB5	PRKCE	ENSSSCP00000031679	ENSSSCP00000009012	G protein subunit beta 5.	Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...]	0.923
GNB5	RRAS	ENSSSCP00000031679	ENSSSCP00000003452	G protein subunit beta 5.	RAS related.	0.691
GNB5	RRAS2	ENSSSCP00000031679	ENSSSCP00000038357	G protein subunit beta 5.	Uncharacterized protein.	0.691
GNG10	GNAI3	ENSSSCP00000072165	ENSSSCP00000007279	Guanine nucleotide-binding protein subunit gamma; Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction.	Guanine nucleotide-binding protein G(K) subunit alpha.	0.759

page 1 of 3

Server load: low (24%) [HD]

Permalink

Network

Cooccurrence

Experiments

Coexpression

Databases

Neighborhood

Textmining

Fusion

© STRING Consortium 2025

Credits

Access

Info

About