| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AR | RNF4 | ENSSSCP00000013166 | ENSSSCP00000036433 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | E3 ubiquitin-protein ligase RNF4 isoform 1. | 0.840 |
| AR | SP1 | ENSSSCP00000013166 | ENSSSCP00000037064 | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | Transcription factor Sp1 isoform a. | 0.895 |
| PARP1 | RNF4 | ENSSSCP00000022104 | ENSSSCP00000036433 | Poly [ADP-ribose] polymerase. | E3 ubiquitin-protein ligase RNF4 isoform 1. | 0.807 |
| PARP1 | SUMO2 | ENSSSCP00000022104 | ENSSSCP00000018235 | Poly [ADP-ribose] polymerase. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.693 |
| PARP1 | SUMO3 | ENSSSCP00000022104 | ENSSSCP00000041868 | Poly [ADP-ribose] polymerase. | Small ubiquitin-related modifier. | 0.472 |
| PML | RNF4 | ENSSSCP00000002091 | ENSSSCP00000036433 | Promyelocytic leukemia. | E3 ubiquitin-protein ligase RNF4 isoform 1. | 0.943 |
| PML | SP1 | ENSSSCP00000002091 | ENSSSCP00000037064 | Promyelocytic leukemia. | Transcription factor Sp1 isoform a. | 0.737 |
| PML | SUMO1 | ENSSSCP00000002091 | ENSSSCP00000071874 | Promyelocytic leukemia. | Small ubiquitin-related modifier 1. | 0.948 |
| PML | SUMO2 | ENSSSCP00000002091 | ENSSSCP00000018235 | Promyelocytic leukemia. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.702 |
| PML | SUMO3 | ENSSSCP00000002091 | ENSSSCP00000041868 | Promyelocytic leukemia. | Small ubiquitin-related modifier. | 0.603 |
| RNF114 | RNF4 | ENSSSCP00000049061 | ENSSSCP00000036433 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] | E3 ubiquitin-protein ligase RNF4 isoform 1. | 0.818 |
| RNF114 | SUMO3 | ENSSSCP00000049061 | ENSSSCP00000041868 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] | Small ubiquitin-related modifier. | 0.455 |
| RNF114 | UBE2D1 | ENSSSCP00000049061 | ENSSSCP00000038770 | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] | Ubiquitin-conjugating enzyme E2 D1 isoform 1; Belongs to the ubiquitin-conjugating enzyme family. | 0.790 |
| RNF4 | AR | ENSSSCP00000036433 | ENSSSCP00000013166 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Androgen receptor; Steroid hormone receptors are ligand-activated transcription factors that regulate eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Transcription factor activity is modulated by bound coactivator and corepressor proteins like ZBTB7A that recruits NCOR1 and NCOR2 to the androgen response elements/ARE on target genes, negatively regulating androgen receptor signaling and androgen-induced cell proliferation. Transcription activation is also down-regulated by NR0B2. Activated, but not phosphorylated, by HIPK3 and ZIPK/DAPK3. | 0.840 |
| RNF4 | PARP1 | ENSSSCP00000036433 | ENSSSCP00000022104 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Poly [ADP-ribose] polymerase. | 0.807 |
| RNF4 | PML | ENSSSCP00000036433 | ENSSSCP00000002091 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Promyelocytic leukemia. | 0.943 |
| RNF4 | RNF114 | ENSSSCP00000036433 | ENSSSCP00000049061 | E3 ubiquitin-protein ligase RNF4 isoform 1. | E3 ubiquitin-protein ligase RNF114; E3 ubiquitin-protein ligase that promotes the ubiquitination of various substrates. In turn, participates in the regulation of many biological processes including cell cycle, apoptosis, osteoclastogenesis as well as innate or adaptive immunity. Acts as negative regulator of NF-kappa-B-dependent transcription by promoting the ubiquitination and stabilization of the NF-kappa-B inhibitor TNFAIP3. May promote the ubiquitination of TRAF6 as well. Acts also as a negative regulator of T-cell activation. Inhibits cellular dsRNA responses and interferon produ [...] | 0.818 |
| RNF4 | SP1 | ENSSSCP00000036433 | ENSSSCP00000037064 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Transcription factor Sp1 isoform a. | 0.919 |
| RNF4 | SUMO1 | ENSSSCP00000036433 | ENSSSCP00000071874 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Small ubiquitin-related modifier 1. | 0.980 |
| RNF4 | SUMO2 | ENSSSCP00000036433 | ENSSSCP00000018235 | E3 ubiquitin-protein ligase RNF4 isoform 1. | Small ubiquitin-related modifier 2; Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO [...] | 0.914 |
