STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
IL2Interleukin-2 precursor; Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine- activated killer cells, natural killer cells, and glioma cells (154 aa)    
Predicted Functional Partners:
IL2RA
Interleukin-2 receptor subunit alpha precursor; Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells
   
 0.999
IL2RG
Cytokine receptor common subunit gamma precursor; Uncharacterized protein; Sus scrofa interleukin 2 receptor, gamma (IL2RG), mRNA
    
 0.998
FOXP3
Uncharacterized protein; Forkhead box P3
    
 
 0.981
JAK3
Tyrosine-protein kinase jak3 isoform x1; Janus kinase 3
     
 0.980
ENSSSCP00000021963
Uncharacterized protein
    
 0.978
IL2RB
Interleukin 2 receptor subunit beta
    
 0.978
JAK1
Tyrosine-protein kinase jak1; Janus kinase 1
     
 0.974
IL6
Interleukin-6 precursor; Sus scrofa interleukin 6 (interferon, beta 2) (IL6), mRNA
      
 0.924
ENSSSCP00000024026
annotation not available
      
 0.924
IL18
Interleukin-18 precursor; Interleukin-18; Augments natural killer cell activity in spleen cells and stimulates interferon gamma production in T-helper type I cells
      
 0.920
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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