STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
SNCAAlpha-synuclein; May be involved in the regulation of dopamine release and transport (140 aa)    
Predicted Functional Partners:
LRRK2
Uncharacterized protein; Sus scrofa leucine-rich repeat kinase 2 (LRRK2), mRNA
   
 
 0.884
PINK1
PTEN induced putative kinase 1
   
 
 0.847
SNCAIP
Uncharacterized protein; Sus scrofa synuclein, alpha interacting protein (SNCAIP), transcript variant 1a, mRNA
    
 
 0.835
PARK7
Protein DJ-1
    
 
 0.796
APP
Amyloid-beta A4 protein; Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Involved in cell mobility and transcription regulation through protein-protein interactions (By similarity). Can promote transcription activation through binding to APBB1-KAT5 and inhibit Notch signaling through interaction with Numb (By similarity). Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP (By similarity). Inhibits G(o) alpha ATPase activity (By similarity). Act [...]
   
 
 0.764
PARK2
E3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily
    
 
 0.726
HDH
Uncharacterized protein; Sus scrofa huntingtin (HDH), mRNA
    
 
 0.724
SLC6A3
Transporter; Solute carrier family 6 (neurotransmitter transporter), member 3; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family
   
 
 0.715
MAPT
Microtubule-associated protein tau
   
 
 0.713
MECOM
MDS1 and EVI1 complex locus
      
 0.673
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, Sus scrofa, pig, pigs, swine, wild boar
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