node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
COPS2 | COPS3 | ENSSSCP00000005012 | ENSSSCP00000060077 | COP9 signalosome subunit 2. | COP9 signalosome subunit 3. | 0.996 |
COPS2 | COPS4 | ENSSSCP00000005012 | ENSSSCP00000009855 | COP9 signalosome subunit 2. | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] | 0.996 |
COPS2 | COPS5 | ENSSSCP00000005012 | ENSSSCP00000040435 | COP9 signalosome subunit 2. | COP9 signalosome subunit 5. | 0.996 |
COPS2 | COPS6 | ENSSSCP00000005012 | ENSSSCP00000041142 | COP9 signalosome subunit 2. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.995 |
COPS2 | COPS7A | ENSSSCP00000005012 | ENSSSCP00000000737 | COP9 signalosome subunit 2. | COP9 signalosome subunit 7A. | 0.975 |
COPS2 | COPS7B | ENSSSCP00000005012 | ENSSSCP00000034082 | COP9 signalosome subunit 2. | COP9 signalosome subunit 7B. | 0.965 |
COPS2 | COPS8 | ENSSSCP00000005012 | ENSSSCP00000017295 | COP9 signalosome subunit 2. | COP9 signalosome subunit 8. | 0.996 |
COPS2 | GPS1 | ENSSSCP00000005012 | ENSSSCP00000039376 | COP9 signalosome subunit 2. | G protein pathway suppressor 1. | 0.995 |
COPS2 | NEDD8 | ENSSSCP00000005012 | ENSSSCP00000042178 | COP9 signalosome subunit 2. | NEDD8 ubiquitin like modifier. | 0.831 |
COPS2 | PPP1R42 | ENSSSCP00000005012 | ENSSSCP00000033024 | COP9 signalosome subunit 2. | Protein phosphatase 1 regulatory subunit 42. | 0.894 |
COPS3 | COPS2 | ENSSSCP00000060077 | ENSSSCP00000005012 | COP9 signalosome subunit 3. | COP9 signalosome subunit 2. | 0.996 |
COPS3 | COPS4 | ENSSSCP00000060077 | ENSSSCP00000009855 | COP9 signalosome subunit 3. | COP9 signalosome complex subunit 4; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). Also involved in the deneddylation of non-cullin subunits such as STON2 (By similarity). The complex is also involved in phosphorylation of p53 [...] | 0.998 |
COPS3 | COPS5 | ENSSSCP00000060077 | ENSSSCP00000040435 | COP9 signalosome subunit 3. | COP9 signalosome subunit 5. | 0.995 |
COPS3 | COPS6 | ENSSSCP00000060077 | ENSSSCP00000041142 | COP9 signalosome subunit 3. | COP9 signalosome complex subunit 6; Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes (By similarity). The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2 (By similarity). The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8, possibly via its association with [...] | 0.995 |
COPS3 | COPS7A | ENSSSCP00000060077 | ENSSSCP00000000737 | COP9 signalosome subunit 3. | COP9 signalosome subunit 7A. | 0.989 |
COPS3 | COPS7B | ENSSSCP00000060077 | ENSSSCP00000034082 | COP9 signalosome subunit 3. | COP9 signalosome subunit 7B. | 0.976 |
COPS3 | COPS8 | ENSSSCP00000060077 | ENSSSCP00000017295 | COP9 signalosome subunit 3. | COP9 signalosome subunit 8. | 0.995 |
COPS3 | GPS1 | ENSSSCP00000060077 | ENSSSCP00000039376 | COP9 signalosome subunit 3. | G protein pathway suppressor 1. | 0.997 |
COPS3 | NEDD8 | ENSSSCP00000060077 | ENSSSCP00000042178 | COP9 signalosome subunit 3. | NEDD8 ubiquitin like modifier. | 0.858 |
COPS3 | PPP1R42 | ENSSSCP00000060077 | ENSSSCP00000033024 | COP9 signalosome subunit 3. | Protein phosphatase 1 regulatory subunit 42. | 0.885 |