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The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DLEU7Deleted in lymphocytic leukemia 7. (221 aa)    
Predicted Functional Partners:
KLHL35
Kelch like family member 35.
      
 0.850
ADAM30
ADAM metallopeptidase domain 30.
      
 0.764
CYP2W1
Cytochrome P450 family 2 subfamily W member 1; Belongs to the cytochrome P450 family.
      
 0.760
DEGS2
Delta 4-desaturase, sphingolipid 2.
      
 0.729
FAM124A
Family with sequence similarity 124 member A.
      
 0.729
CDH22
Cadherin 22; Cadherins are calcium-dependent cell adhesion proteins.
      
 0.723
CEND1
Cell cycle exit and neuronal differentiation protein 1; Involved in neuronal differentiation.
      
 0.721
RNASEH2B
Ribonuclease H2 subunit B.
      
 0.686
TOP1MT
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus r [...]
      
 0.670
RAB11FIP3
RAB11 family interacting protein 3.
      
 0.663
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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