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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ITM2BIntegral membrane protein 2B; Plays a regulatory role in the processing of the amyloid-beta A4 precursor protein (APP) and acts as an inhibitor of the amyloid-beta peptide aggregation and fibrils deposition. Plays a role in the induction of neurite outgrowth. Functions as a protease inhibitor by blocking access of secretases to APP cleavage sites (By similarity). Bri23 peptide prevents aggregation of APP amyloid-beta protein 42 into toxic oligomers; Belongs to the ITM2 family. (266 aa)    
Predicted Functional Partners:
PIANP
PILR alpha-associated neural protein isoform a.
      
 0.678
GNB1L
G protein subunit beta 1 like.
      
 0.673
A0A287BDP1_PIG
Uncharacterized protein.
      
 0.654
VXN
Vexin.
      
 0.556
RNF144A
RBR-type E3 ubiquitin transferase.
      
 0.555
KIFC3
Kinesin-like protein; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.
      
 0.554
FAM227B
Family with sequence similarity 227 member B.
      
 0.554
DMTF1
Cyclin D binding myb like transcription factor 1.
   
  
 0.533
ZC3H10
Zinc finger CCCH-type containing 10.
      
 0.530
AJAP1
Adherens junctions associated protein 1.
      
 0.530
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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