STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
LRCH1Leucine rich repeats and calponin homology domain containing 1. (771 aa)    
Predicted Functional Partners:
CTIF
Cap binding complex dependent translation initiation factor.
      
 0.887
DOCK8
Dedicator of cytokinesis 8; Belongs to the DOCK family.
   
 
 0.779
GJB7
Gap junction protein; One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.
      
 0.779
ZFAND4
Zinc finger AN1-type containing 4.
    
 
 0.761
LRP10
LDL receptor related protein 10.
    
 
 0.735
PPARGC1A
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha; Transcriptional coactivator for steroid receptors and nuclear receptors. Greatly increases the transcriptional activity of PPARG and thyroid hormone receptor on the uncoupling protein promoter. Can regulate key mitochondrial genes that contribute to the program of adaptive thermogenesis. Plays an essential role in metabolic reprogramming in response to dietary availability through coordination of the expression of a wide array of genes involved in glucose and fatty acid metabolism. Induces the expression of PERM1 in [...]
   
 
 0.699
GSK3B
Glycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily.
    
 
 0.663
ERBB2
Receptor protein-tyrosine kinase.
   
 
 0.660
DOCK6
Dedicator of cytokinesis 6; Belongs to the DOCK family.
   
 
 0.652
ATN1
Atrophin-1.
   
  
 0.643
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.