| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| AMBP | C5 | ENSSSCP00000029018 | ENSSSCP00000043852 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | 0.628 |
| AMBP | CPB2 | ENSSSCP00000029018 | ENSSSCP00000010046 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Carboxypeptidase B2 isoform 1 preproprotein. | 0.763 |
| AMBP | CPN1 | ENSSSCP00000029018 | ENSSSCP00000011235 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Carboxypeptidase N catalytic chain. | 0.526 |
| AMBP | F2 | ENSSSCP00000029018 | ENSSSCP00000014081 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.937 |
| AMBP | PLG | ENSSSCP00000029018 | ENSSSCP00000069662 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.861 |
| C5 | AMBP | ENSSSCP00000043852 | ENSSSCP00000029018 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | 0.628 |
| C5 | CPB2 | ENSSSCP00000043852 | ENSSSCP00000010046 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | Carboxypeptidase B2 isoform 1 preproprotein. | 0.775 |
| C5 | CPN1 | ENSSSCP00000043852 | ENSSSCP00000011235 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | Carboxypeptidase N catalytic chain. | 0.459 |
| C5 | F2 | ENSSSCP00000043852 | ENSSSCP00000014081 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.861 |
| C5 | PLG | ENSSSCP00000043852 | ENSSSCP00000069662 | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.706 |
| CEL | CPB1 | ENSSSCP00000027456 | ENSSSCP00000012464 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Carboxypeptidase B. | 0.558 |
| CEL | CPB2 | ENSSSCP00000027456 | ENSSSCP00000010046 | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | Carboxypeptidase B2 isoform 1 preproprotein. | 0.577 |
| CPB1 | CEL | ENSSSCP00000012464 | ENSSSCP00000027456 | Carboxypeptidase B. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.558 |
| CPB1 | CPB2 | ENSSSCP00000012464 | ENSSSCP00000010046 | Carboxypeptidase B. | Carboxypeptidase B2 isoform 1 preproprotein. | 0.916 |
| CPB1 | CPE | ENSSSCP00000012464 | ENSSSCP00000009445 | Carboxypeptidase B. | Carboxypeptidase E. | 0.909 |
| CPB1 | PLG | ENSSSCP00000012464 | ENSSSCP00000069662 | Carboxypeptidase B. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.667 |
| CPB2 | AMBP | ENSSSCP00000010046 | ENSSSCP00000029018 | Carboxypeptidase B2 isoform 1 preproprotein. | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization; In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | 0.763 |
| CPB2 | C5 | ENSSSCP00000010046 | ENSSSCP00000043852 | Carboxypeptidase B2 isoform 1 preproprotein. | Complement C5a anaphylatoxin; Derived from proteolytic degradation of complement C5, C5 anaphylatoxin is a mediator of local inflammatory process. Binding to the receptor C5AR1 induces a variety of responses including intracellular calcium release, contraction of smooth muscle, increased vascular permeability, and histamine release from mast cells and basophilic leukocytes. C5a is also a potent chemokine which stimulates the locomotion of polymorphonuclear leukocytes and directs their migration toward sites of inflammation. | 0.775 |
| CPB2 | CEL | ENSSSCP00000010046 | ENSSSCP00000027456 | Carboxypeptidase B2 isoform 1 preproprotein. | Carboxylic ester hydrolase; Belongs to the type-B carboxylesterase/lipase family. | 0.577 |
| CPB2 | CPB1 | ENSSSCP00000010046 | ENSSSCP00000012464 | Carboxypeptidase B2 isoform 1 preproprotein. | Carboxypeptidase B. | 0.916 |
STRING v12.5 is now available!
