AKAP11 protein (Sus scrofa) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Knowledge-based Evidence

from curated databases

textmining

Assay-based Predictions

experimentally determined

co-expression

Genomic Predictions

gene neighborhood

gene co-occurrence

gene fusions

Your Input:

Neighborhood

Gene Fusion

Co-occurrence

Co-expression

Experiments

Databases

Textmining

[Homology]

Score

AKAP11

A-kinase anchoring protein 11. (1902 aa)

Predicted Functional Partners:

AKAP8

0.794

I3LSZ9_PIG

0.776

AKAP13

0.769

PRKACA

0.726

DMXL1

0.717

PRKACB

0.711

AKAP12

0.698

PRKAR1A

0.678

PRKAR1B

0.678

AKAP1

0.676

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AKAP1	AKAP11	ENSSSCP00000057370	ENSSSCP00000010069	Tudor domain-containing protein.	A-kinase anchoring protein 11.	0.676
AKAP1	AKAP12	ENSSSCP00000057370	ENSSSCP00000038433	Tudor domain-containing protein.	A-kinase anchoring protein 12.	0.702
AKAP1	AKAP13	ENSSSCP00000057370	ENSSSCP00000002454	Tudor domain-containing protein.	Uncharacterized protein.	0.615
AKAP1	AKAP8	ENSSSCP00000057370	ENSSSCP00000014710	Tudor domain-containing protein.	A-kinase anchoring protein 8; Belongs to the AKAP95 family.	0.622
AKAP1	I3LSZ9_PIG	ENSSSCP00000057370	ENSSSCP00000027242	Tudor domain-containing protein.	Uncharacterized protein.	0.618
AKAP1	PRKACA	ENSSSCP00000057370	ENSSSCP00000035101	Tudor domain-containing protein.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.887
AKAP1	PRKACB	ENSSSCP00000057370	ENSSSCP00000058922	Tudor domain-containing protein.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.784
AKAP1	PRKAR1A	ENSSSCP00000057370	ENSSSCP00000044093	Tudor domain-containing protein.	cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	0.772
AKAP1	PRKAR1B	ENSSSCP00000057370	ENSSSCP00000058955	Tudor domain-containing protein.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.772
AKAP11	AKAP1	ENSSSCP00000010069	ENSSSCP00000057370	A-kinase anchoring protein 11.	Tudor domain-containing protein.	0.676
AKAP11	AKAP12	ENSSSCP00000010069	ENSSSCP00000038433	A-kinase anchoring protein 11.	A-kinase anchoring protein 12.	0.698
AKAP11	AKAP13	ENSSSCP00000010069	ENSSSCP00000002454	A-kinase anchoring protein 11.	Uncharacterized protein.	0.769
AKAP11	AKAP8	ENSSSCP00000010069	ENSSSCP00000014710	A-kinase anchoring protein 11.	A-kinase anchoring protein 8; Belongs to the AKAP95 family.	0.794
AKAP11	DMXL1	ENSSSCP00000010069	ENSSSCP00000034916	A-kinase anchoring protein 11.	Dmx like 1.	0.717
AKAP11	I3LSZ9_PIG	ENSSSCP00000010069	ENSSSCP00000027242	A-kinase anchoring protein 11.	Uncharacterized protein.	0.776
AKAP11	PRKACA	ENSSSCP00000010069	ENSSSCP00000035101	A-kinase anchoring protein 11.	cAMP-dependent protein kinase catalytic subunit alpha; Phosphorylates a large number of substrates in the cytoplasm and the nucleus. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subunits, leading to their subsequent proteolysis. Phosphorylates CDC25B, ABL1, NFKB1, CLDN3, PSMC5/RPT6, PJA2, RYR2, RORA and VASP. RORA is activated by phosphorylation. Required for glucose- mediated adipogenic differentiation increase and osteogenic differentiation inhibition from osteoblasts. Involved in the [...]	0.726
AKAP11	PRKACB	ENSSSCP00000010069	ENSSSCP00000058922	A-kinase anchoring protein 11.	cAMP-dependent protein kinase catalytic subunit beta; Mediates cAMP-dependent signaling triggered by receptor binding to GPCRs. PKA activation regulates diverse cellular processes such as cell proliferation, the cell cycle, differentiation and regulation of microtubule dynamics, chromatin condensation and decondensation, nuclear envelope disassembly and reassembly, as well as regulation of intracellular transport mechanisms and ion flux. Regulates the abundance of compartmentalized pools of its regulatory subunits through phosphorylation of PJA2 which binds and ubiquitinates these subu [...]	0.711
AKAP11	PRKAR1A	ENSSSCP00000010069	ENSSSCP00000044093	A-kinase anchoring protein 11.	cAMP-dependent protein kinase type I-alpha regulatory subunit, N-terminally processed; Regulatory subunit of the cAMP-dependent protein kinases involved in cAMP signaling in cells.	0.678
AKAP11	PRKAR1B	ENSSSCP00000010069	ENSSSCP00000058955	A-kinase anchoring protein 11.	Protein kinase cAMP-dependent type I regulatory subunit beta.	0.678
AKAP12	AKAP1	ENSSSCP00000038433	ENSSSCP00000057370	A-kinase anchoring protein 12.	Tudor domain-containing protein.	0.702