| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| F10 | F2 | ENSSSCP00000010205 | ENSSSCP00000014081 | Uncharacterized protein. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.975 |
| F10 | F3 | ENSSSCP00000010205 | ENSSSCP00000022354 | Uncharacterized protein. | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.860 |
| F10 | F5 | ENSSSCP00000010205 | ENSSSCP00000006704 | Uncharacterized protein. | Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. | 0.960 |
| F10 | F7 | ENSSSCP00000010205 | ENSSSCP00000010206 | Uncharacterized protein. | Uncharacterized protein. | 0.955 |
| F10 | F9 | ENSSSCP00000010205 | ENSSSCP00000013514 | Uncharacterized protein. | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. | 0.910 |
| F10 | FURIN | ENSSSCP00000010205 | ENSSSCP00000055096 | Uncharacterized protein. | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. | 0.762 |
| F10 | GGCX | ENSSSCP00000010205 | ENSSSCP00000060390 | Uncharacterized protein. | Vitamin K-dependent gamma-carboxylase isoform 1. | 0.789 |
| F10 | SERPINC1 | ENSSSCP00000010205 | ENSSSCP00000067774 | Uncharacterized protein. | SERPIN domain-containing protein; Belongs to the serpin family. | 0.986 |
| F10 | TFPI | ENSSSCP00000010205 | ENSSSCP00000048443 | Uncharacterized protein. | Tissue factor pathway inhibitor. | 0.960 |
| F10 | VWF | ENSSSCP00000010205 | ENSSSCP00000000759 | Uncharacterized protein. | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.933 |
| F2 | F10 | ENSSSCP00000014081 | ENSSSCP00000010205 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Uncharacterized protein. | 0.975 |
| F2 | F3 | ENSSSCP00000014081 | ENSSSCP00000022354 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Tissue factor; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade. | 0.679 |
| F2 | F5 | ENSSSCP00000014081 | ENSSSCP00000006704 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Coagulation factor V heavy chain; Coagulation factor V is a cofactor that participates with factor Xa to activate prothrombin to thrombin; Belongs to the multicopper oxidase family. | 0.989 |
| F2 | F7 | ENSSSCP00000014081 | ENSSSCP00000010206 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Uncharacterized protein. | 0.653 |
| F2 | F9 | ENSSSCP00000014081 | ENSSSCP00000013514 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Coagulation factor IXa heavy chain; Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa. | 0.837 |
| F2 | FURIN | ENSSSCP00000014081 | ENSSSCP00000055096 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Furin, paired basic amino acid cleaving enzyme; Belongs to the peptidase S8 family. | 0.793 |
| F2 | GGCX | ENSSSCP00000014081 | ENSSSCP00000060390 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Vitamin K-dependent gamma-carboxylase isoform 1. | 0.867 |
| F2 | SERPINC1 | ENSSSCP00000014081 | ENSSSCP00000067774 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | SERPIN domain-containing protein; Belongs to the serpin family. | 0.999 |
| F2 | TFPI | ENSSSCP00000014081 | ENSSSCP00000048443 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Tissue factor pathway inhibitor. | 0.677 |
| F2 | VWF | ENSSSCP00000014081 | ENSSSCP00000000759 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Von Willebrand factor; Important in the maintenance of hemostasis, it promotes adhesion of platelets to the sites of vascular injury by forming a molecular bridge between sub-endothelial collagen matrix and platelet- surface receptor complex, glycoprotein Ibalpha/IX/V. Also acts as a chaperone for coagulation factor VIII, delivering it to the site of injury, stabilizing its heterodimeric structure and protecting it from premature clearance from plasma (By similarity). | 0.882 |
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