HR protein (Sus scrofa) - STRING interaction network

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[Homology]

Score

HR

JmjC domain-containing protein. (1160 aa)

Predicted Functional Partners:

RAD51

0.527

POLR2F

0.521

RBBP8

0.521

RAD52

0.521

LVRN

0.520

FOXI3

0.518

NSUN5

0.515

WASHC1

0.515

GPN3

0.515

BRCA1

0.511

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BRCA1	HR	ENSSSCP00000034439	ENSSSCP00000010263	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	JmjC domain-containing protein.	0.511
BRCA1	RAD51	ENSSSCP00000034439	ENSSSCP00000005138	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.989
BRCA1	RAD52	ENSSSCP00000034439	ENSSSCP00000044772	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RAD52 homolog, DNA repair protein.	0.907
BRCA1	RBBP8	ENSSSCP00000034439	ENSSSCP00000032131	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	RB binding protein 8, endonuclease.	0.999
FOXI3	HR	ENSSSCP00000041939	ENSSSCP00000010263	Forkhead box I3.	JmjC domain-containing protein.	0.518
GPN3	HR	ENSSSCP00000061970	ENSSSCP00000010263	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	JmjC domain-containing protein.	0.515
GPN3	POLR2F	ENSSSCP00000061970	ENSSSCP00000000120	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	RNA polymerase II subunit F.	0.771
GPN3	WASHC1	ENSSSCP00000061970	ENSSSCP00000058840	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	WH2 domain-containing protein.	0.503
HR	BRCA1	ENSSSCP00000010263	ENSSSCP00000034439	JmjC domain-containing protein.	Breast cancer type 1 susceptibility protein homolog; E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The E3 ubiquitin-protein ligase activity is required for its tumor suppressor function. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain [...]	0.511
HR	FOXI3	ENSSSCP00000010263	ENSSSCP00000041939	JmjC domain-containing protein.	Forkhead box I3.	0.518
HR	GPN3	ENSSSCP00000010263	ENSSSCP00000061970	JmjC domain-containing protein.	GPN-loop GTPase 3; Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import; Belongs to the GPN-loop GTPase family.	0.515
HR	LVRN	ENSSSCP00000010263	ENSSSCP00000015127	JmjC domain-containing protein.	Aminopeptidase.	0.520
HR	NSUN5	ENSSSCP00000010263	ENSSSCP00000008228	JmjC domain-containing protein.	NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	0.515
HR	POLR2F	ENSSSCP00000010263	ENSSSCP00000000120	JmjC domain-containing protein.	RNA polymerase II subunit F.	0.521
HR	RAD51	ENSSSCP00000010263	ENSSSCP00000005138	JmjC domain-containing protein.	DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...]	0.527
HR	RAD52	ENSSSCP00000010263	ENSSSCP00000044772	JmjC domain-containing protein.	RAD52 homolog, DNA repair protein.	0.521
HR	RBBP8	ENSSSCP00000010263	ENSSSCP00000032131	JmjC domain-containing protein.	RB binding protein 8, endonuclease.	0.521
HR	WASHC1	ENSSSCP00000010263	ENSSSCP00000058840	JmjC domain-containing protein.	WH2 domain-containing protein.	0.515
LVRN	HR	ENSSSCP00000015127	ENSSSCP00000010263	Aminopeptidase.	JmjC domain-containing protein.	0.520
NSUN5	HR	ENSSSCP00000008228	ENSSSCP00000010263	NOP2/Sun RNA methyltransferase 5; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.	JmjC domain-containing protein.	0.515