node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
ABCA3 | AQP5 | ENSSSCP00000045311 | ENSSSCP00000000223 | ATP binding cassette subfamily A member 3. | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. | 0.680 |
ABCA3 | NKX2-1 | ENSSSCP00000045311 | ENSSSCP00000054869 | ATP binding cassette subfamily A member 3. | NK2 homeobox 1. | 0.550 |
ABCA3 | SCGB1A1 | ENSSSCP00000045311 | ENSSSCP00000013890 | ATP binding cassette subfamily A member 3. | Secretoglobin family 1A member 1. | 0.532 |
ABCA3 | SCGB3A2 | ENSSSCP00000045311 | ENSSSCP00000020730 | ATP binding cassette subfamily A member 3. | Secretoglobin family 3A member 2. | 0.489 |
ABCA3 | SFTPA1 | ENSSSCP00000045311 | ENSSSCP00000067056 | ATP binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.548 |
ABCA3 | SFTPB | ENSSSCP00000045311 | ENSSSCP00000049863 | ATP binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.894 |
ABCA3 | SFTPC | ENSSSCP00000045311 | ENSSSCP00000010269 | ATP binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.863 |
ABCA3 | SFTPD | ENSSSCP00000045311 | ENSSSCP00000058499 | ATP binding cassette subfamily A member 3. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.478 |
ADGRF5 | SFTPB | ENSSSCP00000001882 | ENSSSCP00000049863 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.759 |
ADGRF5 | SFTPC | ENSSSCP00000001882 | ENSSSCP00000010269 | Adhesion G protein-coupled receptor F5; Belongs to the G-protein coupled receptor 2 family. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.813 |
AGER | SCGB1A1 | ENSSSCP00000001544 | ENSSSCP00000013890 | Advanced glycosylation end-product specific receptor. | Secretoglobin family 1A member 1. | 0.695 |
AGER | SCGB3A2 | ENSSSCP00000001544 | ENSSSCP00000020730 | Advanced glycosylation end-product specific receptor. | Secretoglobin family 3A member 2. | 0.677 |
AGER | SFTPA1 | ENSSSCP00000001544 | ENSSSCP00000067056 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.804 |
AGER | SFTPB | ENSSSCP00000001544 | ENSSSCP00000049863 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein B; Pulmonary surfactant-associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. SP-B increases the collapse pressure of palmitic acid to nearly 70 millinewtons per meter. | 0.811 |
AGER | SFTPC | ENSSSCP00000001544 | ENSSSCP00000010269 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein C; Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces. | 0.866 |
AGER | SFTPD | ENSSSCP00000001544 | ENSSSCP00000058499 | Advanced glycosylation end-product specific receptor. | Pulmonary surfactant-associated protein D; Contributes to the lung's defense against inhaled microorganisms, organic antigens and toxins. Interacts with compounds such as bacterial lipopolysaccharides, oligosaccharides and fatty acids and modulates leukocyte action in immune response. May participate in the extracellular reorganization or turnover of pulmonary surfactant. Binds strongly maltose residues and to a lesser extent other alpha- glucosyl moieties (By similarity); Belongs to the SFTPD family. | 0.700 |
AQP5 | ABCA3 | ENSSSCP00000000223 | ENSSSCP00000045311 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. | ATP binding cassette subfamily A member 3. | 0.680 |
AQP5 | SCGB1A1 | ENSSSCP00000000223 | ENSSSCP00000013890 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. | Secretoglobin family 1A member 1. | 0.505 |
AQP5 | SCGB3A2 | ENSSSCP00000000223 | ENSSSCP00000020730 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. | Secretoglobin family 3A member 2. | 0.609 |
AQP5 | SFTPA1 | ENSSSCP00000000223 | ENSSSCP00000067056 | Aquaporin-5; Forms a water-specific channel (By similarity). Plays an important role in fluid secretion in salivary glands. Required for TRPV4 activation by hypotonicity. Together with TRPV4, controls regulatory volume decrease in salivary epithelial cells. Seems to play a redundant role in water transport in the eye, lung and in sweat glands (By similarity); Belongs to the MIP/aquaporin (TC 1.A.8) family. | Pulmonary surfactant-associated protein A; In presence of calcium ions, it binds to surfactant phospholipids and contributes to lower the surface tension at the air- liquid interface in the alveoli of the mammalian lung and is essential for normal respiration. Enhances the expression of MYO18A/SP-R210 on alveolar macrophages; Belongs to the SFTPA family. | 0.545 |