STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DOCK5Dedicator of cytokinesis 5; Belongs to the DOCK family. (1867 aa)    
Predicted Functional Partners:
ELMO2
Engulfment and cell motility 2.
    
 0.839
ZDHHC22
Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family.
    
 
 0.807
ELMO3
Engulfment and cell motility 3.
  
 
 
 0.786
RAC1
Rac family small GTPase 1.
   
 0.768
IRF2BP1
Interferon regulatory factor 2 binding protein 1.
      
 0.750
RHOG
Uncharacterized protein.
   
 0.696
CRK
CRK proto-oncogene, adaptor protein.
    
 
 0.666
RAC2
Rac family small GTPase 2.
   
 
 0.641
CDC42
Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration. In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (By similarity). Require [...]
   
 0.635
FMN1
Formin 1.
   
  
 0.631
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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