node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CORT | NPY | ENSSSCP00000003688 | ENSSSCP00000041417 | Somatostatin domain-containing protein. | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | 0.667 |
CORT | OPRD1 | ENSSSCP00000003688 | ENSSSCP00000024665 | Somatostatin domain-containing protein. | Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...] | 0.499 |
CORT | OPRK1 | ENSSSCP00000003688 | ENSSSCP00000006677 | Somatostatin domain-containing protein. | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | 0.499 |
CORT | OPRL1 | ENSSSCP00000003688 | ENSSSCP00000033028 | Somatostatin domain-containing protein. | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociceptio [...] | 0.499 |
CORT | PDYN | ENSSSCP00000003688 | ENSSSCP00000031176 | Somatostatin domain-containing protein. | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. | 0.716 |
CORT | PENK | ENSSSCP00000003688 | ENSSSCP00000006655 | Somatostatin domain-containing protein. | Proenkephalin. | 0.638 |
CORT | PMCH | ENSSSCP00000003688 | ENSSSCP00000000917 | Somatostatin domain-containing protein. | Pro-MCH preproprotein. | 0.524 |
CORT | PNOC | ENSSSCP00000003688 | ENSSSCP00000055008 | Somatostatin domain-containing protein. | Nociceptin. | 0.766 |
CORT | POMC | ENSSSCP00000003688 | ENSSSCP00000024582 | Somatostatin domain-containing protein. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.695 |
CORT | SST | ENSSSCP00000003688 | ENSSSCP00000051543 | Somatostatin domain-containing protein. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.970 |
NPY | CORT | ENSSSCP00000041417 | ENSSSCP00000003688 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Somatostatin domain-containing protein. | 0.667 |
NPY | OPRD1 | ENSSSCP00000041417 | ENSSSCP00000024665 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Delta-type opioid receptor; G-protein coupled receptor that functions as receptor for endogenous enkephalins and for a subset of other opioids. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain and in opiate-mediated analgesia. [...] | 0.657 |
NPY | OPRK1 | ENSSSCP00000041417 | ENSSSCP00000006677 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Opioid receptor kappa 1; Belongs to the G-protein coupled receptor 1 family. | 0.587 |
NPY | OPRL1 | ENSSSCP00000041417 | ENSSSCP00000033028 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Nociceptin receptor; G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide- binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociceptio [...] | 0.603 |
NPY | PDYN | ENSSSCP00000041417 | ENSSSCP00000031176 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Alpha-neoendorphin; Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress (By similarity). Leumorphin has a typical opiod activity and may have anti- apoptotic effect. | 0.798 |
NPY | PENK | ENSSSCP00000041417 | ENSSSCP00000006655 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Proenkephalin. | 0.772 |
NPY | PMCH | ENSSSCP00000041417 | ENSSSCP00000000917 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Pro-MCH preproprotein. | 0.707 |
NPY | PNOC | ENSSSCP00000041417 | ENSSSCP00000055008 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Nociceptin. | 0.882 |
NPY | POMC | ENSSSCP00000041417 | ENSSSCP00000024582 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Corticotropin-like intermediary peptide; [Corticotropin]: Stimulates the adrenal glands to release cortisol. [Melanocyte-stimulating hormone beta]: Increases the pigmentation of skin by increasing melanin production in melanocytes. [Met-enkephalin]: Endogenous opiate; Belongs to the POMC family. | 0.974 |
NPY | SST | ENSSSCP00000041417 | ENSSSCP00000051543 | C-flanking peptide of NPY; NPY is implicated in the control of feeding and in secretion of gonadotrophin-release hormone; Belongs to the NPY family. | Somatostatin-14; [Somatostatin-14]: Inhibits the secretion of pituitary hormones, including that of growth hormone/somatotropin (GH1), PRL, ACTH, luteinizing hormone (LH) and TSH. Also impairs ghrelin- and GnRH- stimulated secretion of GH1 and LH; the inhibition of ghrelin- stimulated secretion of GH1 can be further increased by neuronostatin. | 0.962 |