node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AACS | ACAT1 | ENSSSCP00000010417 | ENSSSCP00000025827 | Acetoacetyl-CoA synthetase. | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 0.960 |
AACS | ACAT2 | ENSSSCP00000010417 | ENSSSCP00000047700 | Acetoacetyl-CoA synthetase. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.963 |
AACS | BDH1 | ENSSSCP00000010417 | ENSSSCP00000012603 | Acetoacetyl-CoA synthetase. | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.944 |
AACS | BDH2 | ENSSSCP00000010417 | ENSSSCP00000023473 | Acetoacetyl-CoA synthetase. | 3-hydroxybutyrate dehydrogenase type 2 isoform X2. | 0.932 |
AACS | EHHADH | ENSSSCP00000010417 | ENSSSCP00000024105 | Acetoacetyl-CoA synthetase. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.940 |
AACS | HADH | ENSSSCP00000010417 | ENSSSCP00000053505 | Acetoacetyl-CoA synthetase. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.947 |
AACS | HMGCLL1 | ENSSSCP00000010417 | ENSSSCP00000001608 | Acetoacetyl-CoA synthetase. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.948 |
AACS | HMGCS1 | ENSSSCP00000010417 | ENSSSCP00000017880 | Acetoacetyl-CoA synthetase. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.951 |
AACS | HMGCS2 | ENSSSCP00000010417 | ENSSSCP00000034427 | Acetoacetyl-CoA synthetase. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.952 |
AACS | OXCT1 | ENSSSCP00000010417 | ENSSSCP00000068644 | Acetoacetyl-CoA synthetase. | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.923 |
ACAT1 | AACS | ENSSSCP00000025827 | ENSSSCP00000010417 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetoacetyl-CoA synthetase. | 0.960 |
ACAT1 | ACAT2 | ENSSSCP00000025827 | ENSSSCP00000047700 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Acetyl-CoA acetyltransferase 2; Belongs to the thiolase-like superfamily. Thiolase family. | 0.919 |
ACAT1 | BDH1 | ENSSSCP00000025827 | ENSSSCP00000012603 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | D-beta-hydroxybutyrate dehydrogenase, mitochondrial; Belongs to the short-chain dehydrogenases/reductases (SDR) family. | 0.761 |
ACAT1 | BDH2 | ENSSSCP00000025827 | ENSSSCP00000023473 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxybutyrate dehydrogenase type 2 isoform X2. | 0.564 |
ACAT1 | EHHADH | ENSSSCP00000025827 | ENSSSCP00000024105 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Enoyl-CoA hydratase and 3-hydroxyacyl CoA dehydrogenase; Belongs to the enoyl-CoA hydratase/isomerase family. | 0.970 |
ACAT1 | HADH | ENSSSCP00000025827 | ENSSSCP00000053505 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.991 |
ACAT1 | HMGCLL1 | ENSSSCP00000025827 | ENSSSCP00000001608 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxymethyl-3-methylglutaryl-CoA lyase like 1. | 0.950 |
ACAT1 | HMGCS1 | ENSSSCP00000025827 | ENSSSCP00000017880 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | 3-hydroxy-3-methylglutaryl coenzyme A synthase; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase. | 0.991 |
ACAT1 | HMGCS2 | ENSSSCP00000025827 | ENSSSCP00000034427 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Hydroxymethylglutaryl-CoA synthase, mitochondrial; This enzyme condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA, which is the substrate for HMG-CoA reductase; Belongs to the thiolase-like superfamily. HMG-CoA synthase family. | 0.991 |
ACAT1 | OXCT1 | ENSSSCP00000025827 | ENSSSCP00000068644 | Acetyl-CoA acetyltransferase 1; Belongs to the thiolase-like superfamily. Thiolase family. | Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial; Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. | 0.975 |