STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TBX5T-box transcription factor 5. (535 aa)    
Predicted Functional Partners:
NKX2-5
NK2 homeobox 5.
   
 
 0.984
GATA4
Transcription factor GATA-4 isoform 2.
   
 
 0.948
HAND2
Heart-and neural crest derivatives-expressed protein 2.
   
 
 0.896
MEF2C
Myocyte-specific enhancer factor 2C; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex [...]
    
 
 0.892
WWTR1
WW domain containing transcription regulator 1.
    
 0.856
KAT2B
Histone acetyltransferase; Belongs to the acetyltransferase family. GCN5 subfamily.
     
 0.809
HCN4
Hyperpolarization activated cyclic nucleotide gated potassium channel 4.
   
  
 0.808
MYOCD
Myocardin; Smooth muscle cells (SM) and cardiac muscle cells-specific transcriptional factor which uses the canonical single or multiple CArG boxes DNA sequence. Acts as a cofactor of serum response factor (SRF) with the potential to modulate SRF-target genes. Plays a crucial role in cardiogenesis and differentiation of the smooth muscle cell lineage (myogenesis) (By similarity).
   
 
 0.793
ISL1
Insulin gene enhancer protein ISL-1.
    
 
 0.780
YAP1
Yes associated protein 1.
    
 
 0.769
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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