Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
YWHAHTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein eta; Belongs to the 14-3-3 family. (246 aa)    
Predicted Functional Partners:
BAD
BCL2 associated agonist of cell death.
    
 0.983
CDC25C
M-phase inducer phosphatase 3; Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. Directly dephosphorylates CDK1 and activates its kinase activity. When phosphorylated, highly effective in activating G2 cells into prophase (By similarity).
    
 0.975
BRAF
B-Raf proto-oncogene, serine/threonine kinase.
    
 0.975
CDC25B
M-phase inducer phosphatase 2 isoform 1.
    
 0.973
WWTR1
WW domain containing transcription regulator 1.
    
 0.954
FOXO3
Forkhead box protein O3 isoform X1.
    
 0.953
RAF1
RAF proto-oncogene serine/threonine-protein kinase isoform a.
    
 0.940
ARAF
Serine/threonine-protein kinase A-Raf; Involved in the transduction of mitogenic signals from the cell membrane to the nucleus. May also regulate the TOR signaling cascade (By similarity).
    
 0.940
YAP1
Yes associated protein 1.
    
 0.933
LOC100523244
Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.
    
 0.928
Your Current Organism:
Sus scrofa
NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar
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