TOP3B protein (Sus scrofa) - STRING interaction network

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TOP3B

DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family. (155 aa)

Predicted Functional Partners:

FANCM

0.981

TDRD3

0.972

WRN

0.912

MUS81

0.871

TOP2A

0.788

RMI1

0.783

BRS3

0.751

SSBP1

0.738

BLM

0.729

RECQL5

0.711

Your Current Organism:

Sus scrofa

NCBI taxonomy Id: 9823
Other names: S. scrofa, pig, pigs, swine, wild boar

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BLM	FANCM	ENSSSCP00000001986	ENSSSCP00000021205	BLM RecQ like helicase.	FA complementation group M.	0.998
BLM	MUS81	ENSSSCP00000001986	ENSSSCP00000013794	BLM RecQ like helicase.	MUS81 structure-specific endonuclease subunit.	0.951
BLM	RECQL5	ENSSSCP00000001986	ENSSSCP00000034802	BLM RecQ like helicase.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.400
BLM	RMI1	ENSSSCP00000001986	ENSSSCP00000011690	BLM RecQ like helicase.	RecQ mediated genome instability 1.	0.994
BLM	SSBP1	ENSSSCP00000001986	ENSSSCP00000044956	BLM RecQ like helicase.	Single stranded DNA binding protein 1.	0.423
BLM	TDRD3	ENSSSCP00000001986	ENSSSCP00000061758	BLM RecQ like helicase.	Tudor domain containing 3.	0.704
BLM	TOP2A	ENSSSCP00000001986	ENSSSCP00000018518	BLM RecQ like helicase.	DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.	0.644
BLM	TOP3B	ENSSSCP00000001986	ENSSSCP00000010751	BLM RecQ like helicase.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.729
BLM	WRN	ENSSSCP00000001986	ENSSSCP00000016786	BLM RecQ like helicase.	WRN RecQ like helicase.	0.711
BRS3	TOP3B	ENSSSCP00000052910	ENSSSCP00000010751	Bombesin receptor subtype 3; Belongs to the G-protein coupled receptor 1 family.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.751
FANCM	BLM	ENSSSCP00000021205	ENSSSCP00000001986	FA complementation group M.	BLM RecQ like helicase.	0.998
FANCM	MUS81	ENSSSCP00000021205	ENSSSCP00000013794	FA complementation group M.	MUS81 structure-specific endonuclease subunit.	0.993
FANCM	RECQL5	ENSSSCP00000021205	ENSSSCP00000034802	FA complementation group M.	ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.	0.984
FANCM	RMI1	ENSSSCP00000021205	ENSSSCP00000011690	FA complementation group M.	RecQ mediated genome instability 1.	0.999
FANCM	TDRD3	ENSSSCP00000021205	ENSSSCP00000061758	FA complementation group M.	Tudor domain containing 3.	0.980
FANCM	TOP2A	ENSSSCP00000021205	ENSSSCP00000018518	FA complementation group M.	DNA topoisomerase 2-alpha; Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double- strand breaks. Essential during mitosis and meiosis for proper segregation of daughter chromosomes. May play a role in regulating the period length of ARNTL/BMAL1 transcriptional oscillation.	0.445
FANCM	TOP3B	ENSSSCP00000021205	ENSSSCP00000010751	FA complementation group M.	DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.	0.981
FANCM	WRN	ENSSSCP00000021205	ENSSSCP00000016786	FA complementation group M.	WRN RecQ like helicase.	0.989
MUS81	BLM	ENSSSCP00000013794	ENSSSCP00000001986	MUS81 structure-specific endonuclease subunit.	BLM RecQ like helicase.	0.951
MUS81	FANCM	ENSSSCP00000013794	ENSSSCP00000021205	MUS81 structure-specific endonuclease subunit.	FA complementation group M.	0.993

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